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  Presynaptic inhibition of elicited neurotransmitter release

Wu, L.-G., & Saggau, P. (1997). Presynaptic inhibition of elicited neurotransmitter release. Trends in Neurosciences, 20(5), 204-212. doi:10.1016/S0166-2236(96)01015-6.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-CEFF-0 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-CF00-2
Genre: Zeitschriftenartikel
Alternativer Titel : Presynaptic inhibition of elicited neurotransmitter release

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TiNS_20_1997_204.pdf (beliebiger Volltext), 656KB
 
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 Urheber:
Wu, Ling-Gang1, Autor              
Saggau, Peter, Autor
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Schlagwörter: synaptic transmission; presynaptic inhibition; neurotransmitter release; voltage−dependent calcium channel; neuromodulator; presynaptic receptor; cooperative mechanisms
 Zusammenfassung: Activation of presynaptic receptors for a variety of neurotransmitters and neuromodulators inhibits transmitter release at many synapses. Such presynaptic inhibition might serve as a means of adjusting synaptic strength or preventing excessive transmitter release, or both. Previous evidence showed that presynaptic modulators inhibit Ca2+ channels and activate K+ channels at neuronal somata. These modulators also inhibit spontaneous transmitter release by mechanisms downstream of Ca2+ entry. The relative contribution of the above mechanisms to the inhibition of elicited release has been debated for a long time. Recent evidence at synapses where the relationship between transmitter release and presynaptic Ca2+ influx has been well characterized suggests that inhibition of presynaptic voltage-dependent Ca2+ channels plays the major role in presynaptic inhibition of elicited neurotransmitter release. In addition, modulation of the release machinery might contribute to inhibition of elicited release

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Sprache(n): eng - Englisch
 Datum: 1997-05-01
 Publikationsstatus: Im Druck publiziert
 Seiten: 9
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Art des Abschluß: -

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Titel: Trends in Neurosciences
  Andere : Trends Neurosci.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford : Elsevier Current Trends
Seiten: - Band / Heft: 20 (5) Artikelnummer: - Start- / Endseite: 204 - 212 Identifikator: ISSN: 0166-2236
CoNE: /journals/resource/954927741850