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  Structural basis of transcription initiation by RNA polymerase II.

Sainsbury, S., Bernecky, C., & Cramer, P. (2015). Structural basis of transcription initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology, 16(3), 129-143. doi:10.1038/nrm3952.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-E213-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0CB5-3
Genre: Journal Article

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2104030.pdf (Publisher version), 2MB
 
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 Creators:
Sainsbury, S., Author
Bernecky, C., Author
Cramer, P.1, Author              
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1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: Transcription of eukaryotic protein-coding genes commences with the assembly of a conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general transcription factors, at promoter DNA. After two decades of research, the structural basis of transcription initiation is emerging. Crystal structures of many components of the initiation complex have been resolved, and structural information on Pol II complexes with general transcription factors has recently been obtained. Although mechanistic details await elucidation, available data outline how Pol II cooperates with the general transcription factors to bind to and open promoter DNA, and how Pol II directs RNA synthesis and escapes from the promoter.

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Language(s): eng - English
 Dates: 2015-02-182015-03
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/nrm3952
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Title: Nature Reviews Molecular Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 16 (3) Sequence Number: - Start / End Page: 129 - 143 Identifier: -