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  Alcohol affects the brain's resting-state network in social drinkers

Lithari, C., Klados, M., Pappas, C., Albani, M., Kapoukranidou, D., Kovatsi, L., et al. (2012). Alcohol affects the brain's resting-state network in social drinkers. PLoS One, 7(10): e48641. doi:10.1371/journal.pone.0048641.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-0236-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CD68-2
Genre: Journal Article

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 Creators:
Lithari, Chrysa1, Author
Klados, Manousos1, Author              
Pappas, Costas1, Author
Albani, Maria2, Author
Kapoukranidou, Dorothea2, Author
Kovatsi, Leda3, Author
Bamidis, Panagiotis D.1, Author
Papadelis, Christos L.4, Author
Barnes, Gareth Robert5, Contributor
Affiliations:
1Laboratory of Medical Informatics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece, ou_persistent22              
2Laboratory of Physiology, Department of Physiology and Pharmacology, Medical School, Aristotle University of Thessaloniki, Greece, ou_persistent22              
3Department of Forensic Medicine and Toxicology, Medical School, Aristotle University of Thessaloniki, Greece, ou_persistent22              
4Department of Neurology, Boston Children's Hospital, Waltham, MA, USA, ou_persistent22              
5Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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 Abstract: Acute alcohol intake is known to enhance inhibition through facilitation of GABAA receptors, which are present in 40% of the synapses all over the brain. Evidence suggests that enhanced GABAergic transmission leads to increased large-scale brain connectivity. Our hypothesis is that acute alcohol intake would increase the functional connectivity of the human brain resting-state network (RSN). To test our hypothesis, electroencephalographic (EEG) measurements were recorded from healthy social drinkers at rest, during eyes-open and eyes-closed sessions, after administering to them an alcoholic beverage or placebo respectively. Salivary alcohol and cortisol served to measure the inebriation and stress levels. By calculating Magnitude Square Coherence (MSC) on standardized Low Resolution Electromagnetic Tomography (sLORETA) solutions, we formed cortical networks over several frequency bands, which were then analyzed in the context of functional connectivity and graph theory. MSC was increased (p<0.05, corrected with False Discovery Rate, FDR corrected) in alpha, beta (eyes-open) and theta bands (eyes-closed) following acute alcohol intake. Graph parameters were accordingly altered in these bands quantifying the effect of alcohol on the structure of brain networks; global efficiency and density were higher and path length was lower during alcohol (vs. placebo, p<0.05). Salivary alcohol concentration was positively correlated with the density of the network in beta band. The degree of specific nodes was elevated following alcohol (vs. placebo). Our findings support the hypothesis that short-term inebriation considerably increases large-scale connectivity in the RSN. The increased baseline functional connectivity can -at least partially- be attributed to the alcohol-induced disruption of the delicate balance between inhibitory and excitatory neurotransmission in favor of inhibitory influences. Thus, it is suggested that short-term inebriation is associated, as expected, to increased GABA transmission and functional connectivity, while long-term alcohol consumption may be linked to exactly the opposite effect.

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Language(s): eng - English
 Dates: 2012-06-082012-09-282012-10-31
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: PMID: 23119078
DOI: 10.1371/journal.pone.0048641
PMC: PMC3485329
Other: Epub 2012
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (10) Sequence Number: e48641 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850