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  Bällchen participates in proliferation control and prevents the differentiation of Drosophila melanogaster neuronal stem cells.

Yakulov, T., Günesdogan, U., Jäckle, H., & Herzig, A. (2014). Bällchen participates in proliferation control and prevents the differentiation of Drosophila melanogaster neuronal stem cells. Biology Open, 3(10), 881-886. doi:10.1242/​bio.20148631.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-0271-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6EE2-5
Genre: Journal Article

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Yakulov, T.1, Author              
Günesdogan, U.1, Author              
Jäckle, H.1, Author              
Herzig, A.1, Author              
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1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              

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 Abstract: Stem cells continuously generate differentiating daughter cells and are essential for tissue homeostasis and development. Their capacity to self-renew as undifferentiated and actively dividing cells is controlled by either external signals from a cellular environment, the stem cell niche, or asymmetric distribution of cell fate determinants during cell division. Here we report that the protein kinase Bällchen (BALL) is required to prevent differentiation as well as to maintain normal proliferation of neuronal stem cells of Drosophila melanogaster, called neuroblasts. Our results show that the brains of ball mutant larvae are severely reduced in size, which is caused by a reduced proliferation rate of the neuroblasts. Moreover, ball mutant neuroblasts gradually lose the expression of the neuroblast determinants Miranda and aPKC, suggesting their premature differentiation. Our results indicate that BALL represents a novel cell intrinsic factor with a dual function regulating the proliferative capacity and the differentiation status of neuronal stem cells during development.

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Language(s): eng - English
 Dates: 2014-09-042014-10-15
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1242/​bio.20148631
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Title: Biology Open
Source Genre: Journal
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Pages: - Volume / Issue: 3 (10) Sequence Number: - Start / End Page: 881 - 886 Identifier: -