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  Deciphering the scaling of single-molecule interactions using Jarzynski's equality

Raman, S., Utzig, T., Baimpos, T., Shrestha, B. R., & Valtiner, M. (2014). Deciphering the scaling of single-molecule interactions using Jarzynski's equality. Nature Communications, 5: 5539. doi:10.1038/ncomms6539.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-02E6-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-5723-5
Genre: Journal Article

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 Creators:
Raman, Sangeetha1, Author              
Utzig, Thomas1, Author              
Baimpos, Theodoros1, Author              
Shrestha, Buddha Ratna1, Author              
Valtiner, Markus1, Author              
Affiliations:
1Interaction Forces and Functional Materials, Interface Chemistry and Surface Engineering, Max-Planck-Institut für Eisenforschung GmbH, Max Planck Society, ou_1863357              

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Free keywords: density; energy; hydrogen bond; Jarzynski equality; lipid bilayer; measurement; molecular interaction; molecular physics; molecule; single molecule force spectroscopy; spectroscopy; surface property; velocity
 Abstract: Unravelling the complexity of the macroscopic world relies on understanding the scaling of single-molecule interactions towards integral macroscopic interactions. Here, we demonstrate the scaling of single acid-amine interactions through a synergistic experimental approach combining macroscopic surface forces apparatus experiments and single-molecule force spectroscopy. This experimental framework is ideal for testing the well-renowned Jarzynski's equality, which relates work performed under non-equilibrium conditions with equilibrium free energy. Macroscopic equilibrium measurements scale linearly with the number density of interfacial bonds, providing acid-amine interaction energies of 10.9 +/- 0.2 kT. Irrespective of how far from equilibrium single-molecule experiments are performed, the Jarzynski's free energy converges to 11 +/- 1 kT. Our results validate the applicability of Jarzynski's equality to unravel the scaling of non-equilibrium single-molecule experiments to scenarios where large numbers of molecules interacts simultaneously in equilibrium. The developed scaling strategy predicts large-scale properties such as adhesion or cell-cell interactions on the basis of single-molecule measurements.

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Language(s): eng - English
 Dates: 2014-112014-11-21
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: ISI: 000345913600003
DOI: 10.1038/ncomms6539
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 5 Sequence Number: 5539 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723