English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Inference of interactions between chromatin modifiers and histone modifications: from ChIP-Seq data to chromatin-signaling

Perner, J., Lasserre, J., Kinkley, S., Vingron, M., & Chung, H.-R. (2014). Inference of interactions between chromatin modifiers and histone modifications: from ChIP-Seq data to chromatin-signaling. Nucleic Acids Research (London), 42(22), 13689-13695. doi:10.1093/nar/gku1234.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-2127-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-6819-C
Genre: Journal Article

Files

show Files
hide Files
:
Perner.pdf (Publisher version), 475KB
Name:
Perner.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2014 Oxford University Press
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Perner, Juliane1, Author              
Lasserre, Julia2, Author              
Kinkley, Sarah3, Author
Vingron, Martin4, Author              
Chung, Ho-Ryun5, Author              
Affiliations:
1IMPRS for Computational Biology and Scientific Computing - IMPRS-CBSC (Kirsten Kelleher), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479666              
2Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
3Max Planck Society, ou_persistent13              
4Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              
5Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479658              

Content

show
hide
Free keywords: -
 Abstract: Chromatin modifiers and histone modifications are components of a chromatin-signaling network involved in transcription and its regulation. The interactions between chromatin modifiers and histone modifications are often unknown, are based on the analysis of few genes or are studied in vitro. Here, we apply computational methods to recover interactions between chromatin modifiers and histone modifications from genome-wide ChIP-Seq data. These interactions provide a high-confidence backbone of the chromatin-signaling network. Many recovered interactions have literature support; others provide hypotheses about yet unknown interactions. We experimentally verified two of these predicted interactions, leading to a link between H4K20me1 and members of the Polycomb Repressive Complexes 1 and 2. Our results suggest that our computationally derived interactions are likely to lead to novel biological insights required to establish the connectivity of the chromatin-signaling network involved in transcription and its regulation.

Details

show
hide
Language(s): eng - English
 Dates: 2014-11-202014-12-16
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/nar/gku1234
ISSN: 1362-4962 (Electronic)0305-1048 (Print)
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nucleic Acids Research (London)
  Other : Nucleic Acids Res
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: 42 (22) Sequence Number: - Start / End Page: 13689 - 13695 Identifier: ISSN: 0305-1048
CoNE: /journals/resource/110992357379342