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  Molecular mechanisms of long ncRNAs in neurological disorders

Vucicevic, D., Schrewe, H., & Ørom, U. A. (2014). Molecular mechanisms of long ncRNAs in neurological disorders. Frontiers in Genetics, 5: 5:48. doi:10.3389/fgene.2014.00048.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-781E-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-781F-B
Genre: Journal Article

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Vučićević.pdf (Publisher version), 851KB
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© 2014 Vučićević, Schrewe and Ørom
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 Creators:
Vucicevic, Dubravka1, Author              
Schrewe, Heinrich2, Author              
Ørom, Ulf Andersson1, Author              
Affiliations:
1Long non-coding RNA (Ulf Andersson Ørom), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479659              
2Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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Free keywords: neurological disorders, long non-coding RNA, protein-RNA interaction, ncRNA, brain development
 Abstract: Long non-coding RNAs (ncRNAs) have added an unexpected layer of complexity in the regulation of gene expression. Mounting evidence now links long ncRNAs to fundamental biological processes such as development and differentiation, and recent research shows important involvement of long ncRNAs in a variety of diseases including neurodegenerative disorders, such as Parkinson's, Alzheimer's, spinocerebellar ataxia, and Huntington's diseases. Furthermore, long ncRNAs are speculated to be implicated in development of psychiatric disorders such as schizophrenia and bipolar disorders. Long ncRNAs contribute to these disorders in diverse ways, from regulation of transcription to modulation of RNA processing and translation. In this review, we describe the diverse mechanisms reported for long ncRNAs, and discuss how they could mechanistically be involved in the development of neurological disorders.

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Language(s): eng - English
 Dates: 2014-03-04
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fgene.2014.00048
ISSN: 1664-8021 (Electronic)
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Title: Frontiers in Genetics
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Media
Pages: - Volume / Issue: 5 Sequence Number: 5:48 Start / End Page: - Identifier: Other: 1664-8021
CoNE: https://pure.mpg.de/cone/journals/resource/1664-8021