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Free keywords:
alkynes; antibiotics; heterocycles; natural products; platinum
Abstract:
Fighting back: A concise route to the pterocarpene derivative erypoegin H, a natural product endowed with considerable activity against a range of methicillin-resistant Staphyllococcus aureus strains and vancomycin-resistant enterococci, has been developed. The key step in the synthesis is a PtCl2-catalyzed carboalkoxylation reaction of an alkyne (see retrosynthesis; Piv=pivaloyl).