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  Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome

Wang, J., Kalyan, S., Steck, N., Turner, L. M., Harr, B., Künzel, S., et al. (2015). Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome. Nature Communications, 6: 6440. doi:10.1038/ncomms7440.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-7330-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-7331-5
Genre: Journal Article

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 Creators:
Wang, Jun1, Author              
Kalyan, Shirin, Author
Steck, Natalie, Author
Turner, Leslie M.2, Author              
Harr, Bettina2, Author              
Künzel, Sven2, Author              
Vallier,, Marie, Author
Häsler, Robert, Author
Franke, Andre, Author
Oberg, Hans-Heinrich, Author
Ibrahim, Saleh M., Author
Grassl, Guntram A., Author
Kabelitz, Dieter, Author
Baines, John F.1, Author              
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              
2Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: Biological sciences; evolution; genetics; microbiology
 Abstract: Recent evidence suggests that natural selection operating on hosts to maintain their microbiome contributes to the emergence of new species, that is, the ‘hologenomic basis of speciation’. Here we analyse the gut microbiota of two house mice subspecies, Mus musculus musculus and M. m. domesticus, across their Central European hybrid zone, in addition to hybrids generated in the lab. Hybrid mice display widespread transgressive phenotypes (that is, exceed or fall short of parental values) in a variety of measures of bacterial community structure, which reveals the importance of stabilizing selection operating on the intestinal microbiome within species. Further genetic and immunological analyses reveal genetic incompatibilities, aberrant immune gene expression and increased intestinal pathology associated with altered community structure among hybrids. These results provide unique insight into the consequences of evolutionary divergence in a vertebrate ‘hologenome’, which may be an unrecognized contributing factor to reproductive isolation in this taxonomic group.

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Language(s): eng - English
 Dates: 2014-07-172015-01-292015-03-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/ncomms7440
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: 10 S. Volume / Issue: 6 Sequence Number: 6440 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723