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  Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila.

Hildebrandt, A., Pflanz, R., Behr, M., Tarp, T., Riedel, D., & Schuh, R. (2015). Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila. Developmental Biology, 400(2), 237-247. doi:10.1016/j.ydbio.2015.02.008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-73EC-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-92CC-2
Genre: Journal Article

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 Creators:
Hildebrandt, A.1, Author              
Pflanz, R.2, Author              
Behr, M., Author
Tarp, T., Author
Riedel, D.3, Author              
Schuh, R.1, Author              
Affiliations:
1Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society, ou_578591              
2Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              
3Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society, ou_578615              

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Free keywords: Epithelial morphogenesis; Septate junction; Tracheal system
 Abstract: Epithelial tissues separate body compartments with different compositions. Tight junctions (TJs) in vertebrates and septate junctions (SJs) in invertebrates control the paracellular flow of molecules between these compartments. This epithelial barrier function of TJs and SJs must be stably maintained in tissue morphogenesis during cell proliferation and cell movement. Here, we show that Bark beetle (Bark), a putative transmembrane scavenger receptor-like protein, is essential for the maturation but not the establishment of SJs in Drosophila. Embryos that lack bark establish functional SJs, but due to rudimentary septae formation during subsequent embryonic development, these become non-functional. Furthermore, cell adhesion is impaired at the lateral cell membrane and the core protein complexes of SJs are mis-localised, but appear to form otherwise normally in such embryos. We propose a model in which Bark acts as a scaffold protein that mediates cell adhesion and mounting of SJ core complexes during cell rearrangement in tissue morphogenesis.

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Language(s): eng - English
 Dates: 2015-02-202015-04-15
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.ydbio.2015.02.008
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Title: Developmental Biology
Source Genre: Journal
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Pages: - Volume / Issue: 400 (2) Sequence Number: - Start / End Page: 237 - 247 Identifier: -