Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila.

Hildebrandt, A., Pflanz, R., Behr, M., Tarp, T., Riedel, D., & Schuh, R. (2015). Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila. Developmental Biology, 400(2), 237-247. doi:10.1016/j.ydbio.2015.02.008.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
2111711.pdf (Verlagsversion), 9MB
Name:
2111711.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-
:
2111711_Suppl.htm (Ergänzendes Material), 56KB
Name:
2111711_Suppl.htm
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
text/html / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Urheber

einblenden:
ausblenden:
 Urheber:
Hildebrandt, A.1, Autor           
Pflanz, R.2, Autor           
Behr, M., Autor
Tarp, T., Autor
Riedel, D.3, Autor           
Schuh, R.1, Autor           
Affiliations:
1Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society, ou_578591              
2Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              
3Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society, ou_578615              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Epithelial morphogenesis; Septate junction; Tracheal system
 Zusammenfassung: Epithelial tissues separate body compartments with different compositions. Tight junctions (TJs) in vertebrates and septate junctions (SJs) in invertebrates control the paracellular flow of molecules between these compartments. This epithelial barrier function of TJs and SJs must be stably maintained in tissue morphogenesis during cell proliferation and cell movement. Here, we show that Bark beetle (Bark), a putative transmembrane scavenger receptor-like protein, is essential for the maturation but not the establishment of SJs in Drosophila. Embryos that lack bark establish functional SJs, but due to rudimentary septae formation during subsequent embryonic development, these become non-functional. Furthermore, cell adhesion is impaired at the lateral cell membrane and the core protein complexes of SJs are mis-localised, but appear to form otherwise normally in such embryos. We propose a model in which Bark acts as a scaffold protein that mediates cell adhesion and mounting of SJ core complexes during cell rearrangement in tissue morphogenesis.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2015-02-202015-04-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.ydbio.2015.02.008
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Developmental Biology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 400 (2) Artikelnummer: - Start- / Endseite: 237 - 247 Identifikator: -