English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo

Werber, M., Wittler, L., Timmermann, B., Grote, P., & Herrmann, B. G. (2014). The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development, 141(11), 2325-2330. doi:10.1242/dev.105858.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-7661-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A6C7-B
Genre: Journal Article

Files

show Files
hide Files
:
Werber.pdf (Publisher version), 2MB
Name:
Werber.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2014 The Company of Biologists Ltd
License:
-

Locators

show

Creators

show
hide
 Creators:
Werber, Martin1, Author              
Wittler, Lars2, Author              
Timmermann, Bernd1, Author              
Grote, Phillip2, Author              
Herrmann, Bernhard G.2, Author              
Affiliations:
1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              
2Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

Content

show
hide
Free keywords: RNA-seq Embryogenesis Long noncoding RNA Mouse Tissue-specific expression Transcriptome
 Abstract: Differential gene expression is a prerequisite for the formation of multiple cell types from the fertilized egg during embryogenesis. Understanding the gene regulatory networks controlling cellular differentiation requires the identification of crucial differentially expressed control genes and, ideally, the determination of the complete transcriptomes of each individual cell type. Here, we have analyzed the transcriptomes of six major tissues dissected from mid-gestational (TS12) mouse embryos. Approximately one billion reads derived by RNA-seq analysis provided extended transcript lengths, novel first exons and alternative transcripts of known genes. We have identified 1375 genes showing tissue-specific expression, providing gene signatures for each of the six tissues. In addition, we have identified 1403 novel putative long noncoding RNA gene loci, 439 of which show differential expression. Our analysis provides the first complete transcriptome data for the mouse embryo. It offers a rich data source for the analysis of individual genes and gene regulatory networks controlling mid-gestational development.

Details

show
hide
Language(s): eng - English
 Dates: 2014-05-062014-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1242/dev.105858
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Development
  Other : Development
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Cambridgeshire : Company of Biologists
Pages: - Volume / Issue: 141 (11) Sequence Number: - Start / End Page: 2325 - 2330 Identifier: ISSN: 0950-1991
CoNE: /journals/resource/954927546241