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  Toward the Total Synthesis of Spirastrellolide A. Part 1: Strategic Considerations and Preparation of the Southern Domain

Fürstner, A., Fenster, M. D. B., Fasching, B., Godbout, C., & Radkowski, K. (2006). Toward the Total Synthesis of Spirastrellolide A. Part 1: Strategic Considerations and Preparation of the Southern Domain. Angewandte Chemie International Edition, 45(33), 5506-5510. doi:10.1002/anie.200601654.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-AD59-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-AD5A-B
Genre: Journal Article

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z601654_s.pdf (Supplementary material), 97KB
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z601654_s.pdf
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application/pdf / [MD5]
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Copyright Date:
2006
Copyright Info:
Wiley-VCH, 69451 Weinheim, Germany
License:
-

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 Creators:
Fürstner, Alois1, Author              
Fenster, Michaël D. B.1, Author              
Fasching, Bernhard1, Author              
Godbout, Cédrickx1, Author              
Radkowski, Karin1, Author              
Affiliations:
1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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Free keywords: antitumor agents; macrolides; natural products; phosphatase inhibitors; total synthesis
 Abstract: North and South: The unique biological activity of the natural product spirastrellolide A renders it an attractive lead for anticancer agents. The southern hemisphere (C1–C25) and the northern hemisphere (including the chlorinated [5,6,6]-bis-spiroacetal entity and the lateral C42–C47 chain) are prepared by concise and efficient routes. Consequently, the entire carbon framework of this potent phosphatase inhibitor, which contains 21 chiral centers, is prepared in an optically active form, and an important step toward structure determination by total synthesis is achieved.

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Language(s): eng - English
 Dates: 2006-04-262006-07-052006-08-18
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.200601654
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
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Affiliations:
Publ. Info: Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA
Pages: - Volume / Issue: 45 (33) Sequence Number: - Start / End Page: 5506 - 5510 Identifier: ISSN: 1521-3773
CoNE: https://pure.mpg.de/cone/journals/resource/0570-0833