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  Total Synthesis of Iejimalide B

Fürstner, A., Nevado, C., Tremblay, M., Chevrier, C., Teplý, F., Aïssa, C., et al. (2006). Total Synthesis of Iejimalide B. Angewandte Chemie International Edition, 45(35), 5837-5842. doi:10.1002/anie.200601860.

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 Creators:
Fürstner, Alois1, Author              
Nevado, Cristina1, Author              
Tremblay, Martin1, Author              
Chevrier, Carine1, Author              
Teplý, Filip1, Author              
Aïssa, Christophe1, Author              
Waser, Mario1, Author              
Affiliations:
1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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Free keywords: anticancer agents; cross-coupling; macrolides; metathesis; natural products
 Abstract: Metathesis to the rescue: Although counterintuitive at first sight, application of ring-closing metathesis (RCM) to a cyclization precursor containing 10 double bonds has led to the selective and high-yielding formation of the macrocyclic core of iejimalide B, a potent cytotoxic agent of marine origin. In contrast, a macrolactonization approach failed to afford this intricate target.

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Language(s): eng - English
 Dates: 2006-05-112006-07-282006-09-04
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.200601860
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA
Pages: - Volume / Issue: 45 (35) Sequence Number: - Start / End Page: 5837 - 5842 Identifier: ISSN: 1521-3773
CoNE: https://pure.mpg.de/cone/journals/resource/0570-0833