English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network

Schulz, E. G., Meisig, J., Nakamura, T., Okamoto, I., Sieber, A., Picard, C., et al. (2014). The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network. Cell Stem Cell, 14(2), 203-2016. doi:10.1016/j.stem.2013.11.022.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-7AF0-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-7AF1-0
Genre: Journal Article

Files

show Files
hide Files
:
Schulz.pdf (Publisher version), 2MB
Name:
Schulz.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2014 Elsevier Inc.
License:
-

Locators

show

Creators

show
hide
 Creators:
Schulz, Edda G.1, Author              
Meisig, Johannes, Author
Nakamura, Tomonori , Author
Okamoto, Ikuhiro , Author
Sieber, Anja, Author
Picard, Christel, Author
Borensztein, Maud, Author
Saitou, Mitinori , Author
Blüthgen, Nils , Author
Heard, Edith, Author
Affiliations:
1Regulatory Networks in Stem Cells (Edda G. Schulz), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117286              

Content

show
hide
Free keywords: -
 Abstract: During early development of female mouse embryos, both X chromosomes are transiently active. X gene dosage is then equalized between the sexes through the process of X chromosome inactivation (XCI). Whether the double dose of X-linked genes in females compared with males leads to sex-specific developmental differences has remained unclear. Using embryonic stem cells with distinct sex chromosome compositions as a model system, we show that two X chromosomes stabilize the naive pluripotent state by inhibiting MAPK and Gsk3 signaling and stimulating the Akt pathway. Since MAPK signaling is required to exit the pluripotent state, differentiation is paused in female cells as long as both X chromosomes are active. By preventing XCI or triggering it precociously, we demonstrate that this differentiation block is released once XX cells have undergone X inactivation. We propose that double X dosage interferes with differentiation, thus ensuring a tight coupling between X chromosome dosage compensation and development.

Details

show
hide
Language(s): eng - English
 Dates: 2014-02-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.stem.2013.11.022
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell Stem Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 14 (2) Sequence Number: - Start / End Page: 203 - 2016 Identifier: ISSN: 1934-5909