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  Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

Pettigrew, K. A., Fajutrao Valles, S. F., Moll, K., Northstone, K., Ring, S., Pennell, C., et al. (2015). Lack of replication for the myosin-18B association with mathematical ability in independent cohorts. Genes, Brain and Behavior, 14(4), 369-376. doi:10.1111/gbb.12213.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0025-A8FA-F Version Permalink: https://hdl.handle.net/21.11116/0000-0002-CDFD-B
Genre: Journal Article

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2015 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd. 369 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Pettigrew, Kerry A.1, Author
Fajutrao Valles, Samuelle F.1, Author
Moll, Kristina2, 3, Author
Northstone, Kate4, Author
Ring, Susan4, Author
Pennell, Craig5, Author
Wang, Carol5, Author
Leavett, Ruth3, Author
Hayiou-Thomas, Marianna E.3, Author
Thompson, Paul6, Author
Simpson, Nuala H.7, Author
Fisher, Simon E.8, 9, Author           
The SLI Consortium, Author              
Whitehouse, Andrew J.O.10, Author
Snowling, Margaret J.6, 11, Author
Newbury, Dianne F.7, 11, Author
Paracchini, Silvia1, Author
Affiliations:
1School of Medicine, University of St Andrews, St Andrews, UK, ou_persistent22              
2Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy Ludwig-Maximilians-University, Munich, Germany, ou_persistent22              
3Department of Psychology, University of York, Heslington, York, UK, ou_persistent22              
4School of Social and Community Medicine, University of Bristol, Bristol, UK, ou_persistent22              
5School of Women's and Infants' Health, University of Western Australia, Crawley, Australia, ou_persistent22              
6Department of Experimental Psychology, Oxford, UK, ou_persistent22              
7Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK, ou_persistent22              
8Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
9Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
10Telethon Kids Institute, University of Western Australia, Crawley, Australia, ou_persistent22              
11St. Johns College, University of Oxford, Oxford, UK, ou_persistent22              

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 Abstract: Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance.

We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible.

We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

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Language(s): eng - English
 Dates: 20152015
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/gbb.12213
 Degree: -

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Title: Genes, Brain and Behavior
Source Genre: Journal
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Publ. Info: Oxford : Blackwell
Pages: - Volume / Issue: 14 (4) Sequence Number: - Start / End Page: 369 - 376 Identifier: ISSN: 1601-1848
CoNE: https://pure.mpg.de/cone/journals/resource/111006469467402