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  The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited tole in the anti-pneumococcal innate immune response

Rabes, A., Zimmermann, S., Reppe, K., Lang, R., Seeberger, P. H., Suttorp, N., et al. (2015). The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited tole in the anti-pneumococcal innate immune response. PLoS One, 10(2): e0117022. doi:10.1371/journal.pone.0117022.

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 Creators:
Rabes, Anne, Author
Zimmermann, Stephanie1, Author              
Reppe, Katrin, Author
Lang, Roland, Author
Seeberger, Peter H.2, Author              
Suttorp, Norbert, Author
Witzenrath, Martin, Author
Lepenies, Bernd1, Author              
Opitz, Bastian, Author
Affiliations:
1Bernd Lepenies, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863298              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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Free keywords: Open Access, imprs-kgf
 Abstract: The innate immune system employs C-type lectin receptors (CLRs) to recognize carbohydrate structures on pathogens and self-antigens. The Macrophage-inducible C-type lectin (Mincle) is a FcRγ-coupled CLR that was shown to bind to mycobacterial cord factor as well as certain fungal species. However, since CLR functions during bacterial infections have not yet been investigated thoroughly, we aimed to examine their function in Streptococcus pneumonia infection. Binding studies using a library of recombinantly expressed CLR-Fc fusion proteins indicated a specific, Ca2+-dependent, and serotype-specific binding of Mincle to S. pneumonia. Subsequent experiments with different Mincle-expressing cells as well as Mincle-deficient mice, however, revealed a limited role of this receptor in bacterial phagocytosis, neutrophil-mediated killing, cytokine production, and antibacterial immune response during pneumonia. Collectively, our results indicate that Mincle is able to recognize S. pneumonia but is not required for the anti-pneumococcal innate immune response.

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 Dates: 2015-02-062015
 Publication Status: Published in print
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 10 (2) Sequence Number: e0117022 Start / End Page: - Identifier: ISSN: 1932-6203