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  Analysis of quantitative trait loci in mice suggests a role of Enoph1 in stress reactivity

Barth, A., Bilkei-Gorzo, A., Drews, E., Otte, D. M., Diaz-Lacava, A., Varadarajulu, J., et al. (2014). Analysis of quantitative trait loci in mice suggests a role of Enoph1 in stress reactivity. Journal of Neurochemistry, 128(6), 807-817. doi:10.1111/jnc.12517.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-BC76-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-BC77-0
Genre: Journal Article

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© 2013 International Society for Neurochemistry
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 Creators:
Barth, A., Author
Bilkei-Gorzo, A., Author
Drews, E., Author
Otte, D. M., Author
Diaz-Lacava, A., Author
Varadarajulu, J., Author
Turck, C. W., Author
Wienker, T. F.1, Author              
Zimmer, A., Author
Affiliations:
1Clinical Genetics (Thomas F. Wienker), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, 1479643              

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Free keywords: Animals Anxiety/*genetics/metabolism/physiopathology Chromosomes, Mammalian/genetics Depression/*genetics/metabolism/physiopathology Female Male Mice Mice, Inbred C3H Mice, Inbred C57BL Multienzyme Complexes/*genetics/metabolism Phenotype Phosphoric Monoester Hydrolases/*genetics/metabolism Polymorphism, Single Nucleotide Quantitative Trait Loci Species Specificity Spermidine/metabolism Stress, Psychological/*genetics/metabolism/physiopathology
 Abstract: Significant progress in elucidating the genetic etiology of anxiety and depression has been made during the last decade through a combination of human and animal studies. In this study, we aimed to discover genetic loci linked with anxiety as well as depression in order to reveal new candidate genes. Therefore, we initially tested the behavioral sensitivity of 543 F2 animals derived from an intercross of C57BL/6J and C3H/HeJ mice in paradigms for anxiety and depression. Next, all animals were genotyped with 269 microsatellite markers with a mean distance of 5.56 cM. Finally, a Quantitative Trait Loci (QTL) analysis was carried out, followed by selection of candidate genes. The QTL analysis revealed several new QTL on chromosome 5 with a common core interval of 19 Mb. We further narrowed this interval by comparative genomics to a region of 15 Mb. A database search and gene prioritization revealed Enoph1 as the most significant candidate gene on the prioritization list for anxiety and also for depression fulfilling our selection criteria. The Enoph1 gene, which is involved in polyamine biosynthesis, is differently expressed in parental strains, which have different brain spermidine levels and show distinct anxiety and depression-related phenotype. Our result suggests a significant role in polyamines in anxiety and depression-related behaviors.

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Language(s): eng - English
 Dates: 2013-11-172014-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/jnc.12517
ISSN: 1471-4159 (Electronic)0022-3042 (Print)
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Title: Journal of Neurochemistry
  Other : J. Neurochem.
Source Genre: Journal
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Publ. Info: John Wiley and Sons
Pages: - Volume / Issue: 128 (6) Sequence Number: - Start / End Page: 807 - 817 Identifier: ISSN: 0022-3042
CoNE: https://pure.mpg.de/cone/journals/resource/954925416956_1