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  A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability

Larti, F., Kahrizi, K., Musante, L., Hu, H., Papari, E., Fattahi, Z., et al. (2015). A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability. European journal of human genetics, 23(3), 331-336. doi:10.1038/ejhg.2014.13.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-C264-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-C265-D
Genre: Journal Article

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© 2014 European Society of Human Genetics
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Larti, F., Author
Kahrizi, K., Author
Musante, L.1, Author              
Hu, H.2, Author              
Papari, E., Author
Fattahi, Z., Author
Bazazzadegan, N., Author
Liu, Z., Author
Banan, M., Author
Garshasbi, M.2, Author              
Wienker, T. F.3, Author              
Ropers, H.-H.2, Author              
Galjart, N., Author
Najmabadi, H., Author
Affiliations:
1Familial Cognitive Disorders (Luciana Musante), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479644              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
3Clinical Genetics (Thomas F. Wienker), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, 1479643              

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 Abstract: In the context of a comprehensive research project, investigating novel autosomal recessive intellectual disability (ARID) genes, linkage analysis based on autozygosity mapping helped identify an intellectual disability locus on Chr.12q24, in an Iranian family (LOD score=3.7). Next-generation sequencing (NGS) following exon enrichment in this novel interval, detected a nonsense mutation (p.Q1010*) in the CLIP1 gene. CLIP1 encodes a member of microtubule (MT) plus-end tracking proteins, which specifically associates with the ends of growing MTs. These proteins regulate MT dynamic behavior and are important for MT-mediated transport over the length of axons and dendrites. As such, CLIP1 may have a role in neuronal development. We studied lymphoblastoid and skin fibroblast cell lines established from healthy and affected patients. RT-PCR and western blot analyses showed the absence of CLIP1 transcript and protein in lymphoblastoid cells derived from affected patients. Furthermore, immunofluorescence analyses showed MT plus-end staining only in fibroblasts containing the wild-type (and not the mutant) CLIP1 protein. Collectively, our data suggest that defects in CLIP1 may lead to ARID.

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Language(s): eng - English
 Dates: 2014-02-262015-03
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/ejhg.2014.13
ISSN: 1476-5438 (Electronic)1018-4813 (Print)
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Title: European journal of human genetics
  Other : Eur. J. Hum. Genet.
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 23 (3) Sequence Number: - Start / End Page: 331 - 336 Identifier: ISSN: 1018-4813
CoNE: https://pure.mpg.de/cone/journals/resource/954925585277_1