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  Protein Transport into the Human Endoplasmic Reticulum

Dudek, J., Pfeffer, S., Lee, P.-H., Jung, M., Cavalié, A., Helms, V., et al. (2015). Protein Transport into the Human Endoplasmic Reticulum. Journal of Molecular Bioloy, 427(6 Part A), 1159-1175. doi:10.1016/j.jmb.2014.06.011.

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 Creators:
Dudek, Johanna, Author
Pfeffer, Stefan1, Author              
Lee, Po-Hsien, Author
Jung, Martin, Author
Cavalié, Adolfo, Author
Helms, Volkhard, Author
Förster, Friedrich1, Author              
Zimmermann, Richard, Author
Affiliations:
1Förster, Friedrich / Modeling of Protein Complexes, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565148              

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Free keywords: driving forces; endoplasmic reticulum; membrane insertion; protein translocation; Sec61 complex
 Abstract: Protein transport into the endoplasmic reticulum (ER) is essential for all eukaryotic cells and evolutionary related to protein transport into and across the cytoplasmic membrane of eubacteria and archaea. It is based on amino-terminal signal peptides in the precursor polypeptides plus various transport components in cytosol plus ER and can occur either cotranslationally or posttranslationally. The two mechanisms merge at the heterotrimeric Sec61 complex in the ER membrane, which forms an aqueous polypeptide-conducting channel. Since the mammalian ER is also the main intracellular calcium storage organelle, the Sec61 complex is tightly regulated in its dynamics between the open and closed conformations by various ligands, such as precursor polypeptides at the cytosolic face and the Hsp70-type molecular chaperone BiP at the ER lumenal face (Hsp, heat shock protein). Furthermore, BiP binding to the incoming precursor polypeptide contributes to unidirectionality and efficiency of transport. Recent insights into the structural dynamics of the Sec61 complex and related complexes in eubacteria and archaea have various mechanistic and functional implications

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Language(s): eng - English
 Dates: 2014-06-232015-03-27
 Publication Status: Published in print
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.jmb.2014.06.011
 Degree: -

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Title: Journal of Molecular Bioloy
  Other : J Mol Biol
  Alternative Title : Elucidation of Protein Translocation Pathways (Part II)
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 427 (6 Part A) Sequence Number: - Start / End Page: 1159 - 1175 Identifier: ISSN: 0022-2836