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  A model for transcription initiation in human mitochondria.

Morozov, Y. I., Parshin, A. V., Agaronyan, K., Cheung, A. C., Anikin, M., Cramer, P., et al. (2015). A model for transcription initiation in human mitochondria. Nucleic Acids Research, 43(7), 3726-3735. doi:10.1093/nar/gkv235.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-A09D-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1A82-8
Genre: Journal Article

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 Creators:
Morozov, Y. I., Author
Parshin, A. V., Author
Agaronyan, K., Author
Cheung, A. C., Author
Anikin, M., Author
Cramer, P.1, Author              
Temiakov, D., Author
Affiliations:
1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: Regulation of transcription of mtDNA is thought to be crucial for maintenance of redox potential and vitality of the cell but is poorly understood at the molecular level. In this study we mapped the binding sites of the core transcription initiation factors TFAM and TFB2M on human mitochondrial RNA polymerase, and interactions of the latter with promoter DNA. This allowed us to construct a detailed structural model, which displays a remarkable level of interaction between the components of the initiation complex (IC). The architecture of the mitochondrial IC suggests mechanisms of promoter binding and recognition that are distinct from the mechanisms found in RNAPs operating in all domains of life, and illuminates strategies of transcription regulation developed at the very early stages of evolution of gene expression.

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Language(s): eng - English
 Dates: 2015-03-23
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/nar/gkv235
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Title: Nucleic Acids Research
Source Genre: Journal
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Pages: - Volume / Issue: 43 (7) Sequence Number: - Start / End Page: 3726 - 3735 Identifier: -