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  Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1

Kanaan, A. S., Frank, F., Maedler-Kron, C., Verma, K., Sonenberg, N., & Nagar, B. (2009). Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65(10), 1060-1064. doi:10.1107/S1744309109036513.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-A131-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-D1DC-8
Genre: Journal Article

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 Creators:
Kanaan, Ahmad S.1, Author              
Frank, Filipp, Author
Maedler-Kron, Chelsea, Author
Verma, Karan, Author
Sonenberg, Nahum, Author
Nagar, Bhushan, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Paip1; PABP; eIF3; eIF4A; eIF4G; Initiation factors; eIFs; mRNA translation; Translational stimulation
 Abstract: The poly(A)-binding protein (PABP) simultaneously interacts with the poly(A) tail of mRNAs and the scaffolding protein eIF4G to mediate mRNA circularization, resulting in stimulation of protein translation. PABP is regulated by the PABP-interacting protein Paip1. Paip1 is thought to act as a translational activator in 5′ cap-dependent translation by interacting with PABP and the initiation factors eIF4A and eIF3. Here, the crystallization and preliminary diffraction analysis of the middle domain of Paip1 (Paip1M), which produces crystals that diffract to a resolution of 2.2 Å, are presented.

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Language(s): eng - English
 Dates: 2009-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1107/S1744309109036513
 Degree: -

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Title: Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Source Genre: Journal
 Creator(s):
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Publ. Info: Blackwell Publishing Limited
Pages: - Volume / Issue: 65 (10) Sequence Number: - Start / End Page: 1060 - 1064 Identifier: ISSN: 1744-3091
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017210_1