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  Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution

Müller, D., Cherukuri, P., Henningfeld, K., Poh, C. H., Wittler, L., Grote, P., et al. (2014). Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution. Science, 343(6176), 1264-1266. doi:10.1126/science.1246448.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-A86D-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-A86E-7
Genre: Journal Article

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© 2014 American Association for the Advancement of Science
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 Creators:
Müller, Daniel, Author
Cherukuri, Pitchaiah, Author
Henningfeld, Kristine, Author
Poh, Chor Hoon, Author
Wittler, Lars1, Author              
Grote, Phillip1, Author              
Schlüter, Oliver, Author
Schmidt, Jennifer, Author
Laborda, Jorge, Author
Bauer, Steven R., Author
Brownstone, Robert M., Author
Marquardt, Till, Author
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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 Abstract: Motor neurons, which relay neural commands to drive skeletal muscle movements, encompass types ranging from “slow” to “fast,” whose biophysical properties govern the timing, gradation, and amplitude of muscle force. Here we identify the noncanonical Notch ligand Delta-like homolog 1 (Dlk1) as a determinant of motor neuron functional diversification. Dlk1, expressed by ~30% of motor neurons, is necessary and sufficient to promote a fast biophysical signature in the mouse and chick. Dlk1 suppresses Notch signaling and activates expression of the K+ channel subunit Kcng4 to modulate delayed-rectifier currents. Dlk1 inactivation comprehensively shifts motor neurons toward slow biophysical and transcriptome signatures, while abolishing peak force outputs. Our findings provide insights into the development of motor neuron functional diversity and its contribution to the execution of movements.

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Language(s): eng - English
 Dates: 2014-03-14
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1126/science.1246448
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 343 (6176) Sequence Number: - Start / End Page: 1264 - 1266 Identifier: ISSN: 0036-8075
CoNE: /journals/resource/991042748276600_1