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  No association between CTNNBL1 and episodic memory performance

Liu, T., Li, S.-C., Papenberg, G., Schröder, J., Roehr, J. T., Nietfeld, W., et al. (2014). No association between CTNNBL1 and episodic memory performance. Translational Psychiatry, 4: e454. doi:10.1038/tp.2014.93.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-AA23-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-AA24-C
Genre: Journal Article

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 Creators:
Liu, Tian1, Author              
Li, Shu-Chen1, Author              
Papenberg, Goran1, Author              
Schröder, Julia1, Author              
Roehr, Johannes T., Author
Nietfeld, Wilfried2, Author              
Lindenberger, Ulman1, Author              
Bertram, Lars3, Author              
Affiliations:
1Center for Lifespan Psychology, Max Planck Institute for Human Development, Max Planck Society, ou_2074288              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
3Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

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 Abstract: Polymorphisms in the gene encoding catenin-β-like 1 (CTNNBL1) were recently reported to be associated with verbal episodic memory performance—in particular, delayed verbal free recall assessed between 5 and 30 min after encoding—in a genome-wide association study on healthy young adults. To further examine the genetic effects of CTNNBL1, we tested for association between 455 single-nucleotide polymorphisms (SNPs) in or near CTNNBL1 and 14 measures of episodic memory performance from three different tasks in 1743 individuals. Probands were part of a population-based study of mentally healthy adult men and women, who were between 20 and 70 years old and were recruited as participants for the Berlin Aging Study II. Associations were assessed using linear regression analysis. Despite having sufficient power to detect the previously reported effect sizes, we found no evidence for statistically significant associations between the tested CTNNBL1 SNPs and any of the 14 measures of episodic memory. The previously reported effects of genetic polymorphisms in CTNNBL1 on episodic memory performance do not generalize to the broad range of tasks assessed in our cohort. If not altogether spurious, the effects may be limited to a very narrow phenotypic domain (that is, verbal delayed free recall between 5 and 30 min). More studies are needed to further clarify the role of CTNNBL1 in human memory.

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Language(s): eng - English
 Dates: 2014-09-30
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 695909
DOI: 10.1038/tp.2014.93
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Title: Translational Psychiatry
Source Genre: Journal
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Pages: - Volume / Issue: 4 Sequence Number: e454 Start / End Page: - Identifier: -