English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Orientation dependence of magnetization transfer parameters in human white matter

Pampel, A., Müller, D. K., Anwander, A., Marschner, H., & Möller, H. E. (2015). Orientation dependence of magnetization transfer parameters in human white matter. NeuroImage, 114, 136-146. doi:10.1016/j.neuroimage.2015.03.068.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-C0BC-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7A6A-E
Genre: Journal Article

Files

show Files
hide Files
:
Pampel_Neuroimage_preprint_2015.pdf (Preprint), 9MB
Name:
Pampel_Neuroimage_preprint_2015.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Pampel, André1, Author              
Müller, Dirk K.1, Author              
Anwander, Alfred2, Author              
Marschner, Henrik1, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

Content

show
hide
Free keywords: Absorption lineshape; Anisotropy; Bingham distribution function; Cerebral white matter; Orientation dependence; Fiber orientation distribution; Quantitative magnetization-transfer imaging; Super-Lorentzian lineshape
 Abstract: Quantification of magnetization-transfer (MT) experiments is typically based on a model comprising a liquid pool "a" of free water and a semisolid pool "b" of motionally restricted macromolecules or membrane compounds. By a comprehensive fitting approach, high quality MT parameter maps of the human brain are obtained. In particular, a distinct correlation between the diffusion-tensor orientation with respect to the B0-magnetic field and the apparent transverse relaxation time, T2b, of the semisolid pool (i.e., the width of its absorption line) is observed. This orientation dependence is quantitatively explained by a refined dipolar lineshape for pool b that explicitly considers the specific geometrical arrangement of lipid bilayers wrapped around a cylindrical axon. The model inherently reduces the myelin membrane to its lipid constituents, which is motivated by previous studies on efficient interaction sites (e.g., cholesterol or galactocerebrosides) in the myelin membrane and on the origin of ultrashort T2 signals in cerebral white matter. The agreement between MT orientation effects and corresponding forward simulations using empirical diffusion imaging results as input as well as results from fits employing the novel lineshape support previous suggestions that the fiber orientation distribution in a voxel can be modeled as a scaled Bingham distribution.

Details

show
hide
Language(s): eng - English
 Dates: 2014-09-172015-03-272015-04-072015-07-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2015.03.068
PMID: 25862261
Other: Epub 2015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 114 Sequence Number: - Start / End Page: 136 - 146 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166