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  Orientation dependence of magnetization transfer parameters in human white matter

Pampel, A., Müller, D. K., Anwander, A., Marschner, H., & Möller, H. E. (2015). Orientation dependence of magnetization transfer parameters in human white matter. NeuroImage, 114, 136-146. doi:10.1016/j.neuroimage.2015.03.068.

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Pampel_Neuroimage_preprint_2015.pdf (Preprint), 9MB
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 Urheber:
Pampel, André1, Autor           
Müller, Dirk K.1, Autor           
Anwander, Alfred2, Autor           
Marschner, Henrik1, Autor           
Möller, Harald E.1, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Schlagwörter: Absorption lineshape; Anisotropy; Bingham distribution function; Cerebral white matter; Orientation dependence; Fiber orientation distribution; Quantitative magnetization-transfer imaging; Super-Lorentzian lineshape
 Zusammenfassung: Quantification of magnetization-transfer (MT) experiments is typically based on a model comprising a liquid pool "a" of free water and a semisolid pool "b" of motionally restricted macromolecules or membrane compounds. By a comprehensive fitting approach, high quality MT parameter maps of the human brain are obtained. In particular, a distinct correlation between the diffusion-tensor orientation with respect to the B0-magnetic field and the apparent transverse relaxation time, T2b, of the semisolid pool (i.e., the width of its absorption line) is observed. This orientation dependence is quantitatively explained by a refined dipolar lineshape for pool b that explicitly considers the specific geometrical arrangement of lipid bilayers wrapped around a cylindrical axon. The model inherently reduces the myelin membrane to its lipid constituents, which is motivated by previous studies on efficient interaction sites (e.g., cholesterol or galactocerebrosides) in the myelin membrane and on the origin of ultrashort T2 signals in cerebral white matter. The agreement between MT orientation effects and corresponding forward simulations using empirical diffusion imaging results as input as well as results from fits employing the novel lineshape support previous suggestions that the fiber orientation distribution in a voxel can be modeled as a scaled Bingham distribution.

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Sprache(n): eng - English
 Datum: 2014-09-172015-03-272015-04-072015-07-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2015.03.068
PMID: 25862261
Anderer: Epub 2015
 Art des Abschluß: -

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 114 Artikelnummer: - Start- / Endseite: 136 - 146 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166