English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The Val/Met polymorphism of the Brain-Derived Neurotrophic Factor (BDNF) gene predicts decline in perceptual speed in older adults

Ghisletta, P., Bäckman, L., Bertram, L., Brandmaier, A. M., Gerstorf, D., Liu, T., et al. (2014). The Val/Met polymorphism of the Brain-Derived Neurotrophic Factor (BDNF) gene predicts decline in perceptual speed in older adults. Psychology and Aging, 29(2), 384-392. doi:10.1037/a0035201.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-B03D-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-B03E-7
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Ghisletta, Paolo, Author              
Bäckman, Lars, Author              
Bertram, Lars1, Author              
Brandmaier, Andreas Markus, Author              
Gerstorf, Denis, Author              
Liu, Tian, Author              
Lindenberger, Ulman, Author              
Affiliations:
1Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

Content

show
hide
Free keywords: -
 Abstract: The brain-derived neurotrophic factor (BDNF) promotes activity-dependent synaptic plasticity, and contributes to learning and memory. We investigated whether a common Val66Met missense polymorphism (rs6265) of the BDNF gene is associated with individual differences in cognitive decline (marked by perceptual speed) in old age. A total of 376 participants of the Berlin Aging Study, with a mean age of 83.9 years at first occasion, were assessed longitudinally up to 11 times across more than 13 years on the Digit-Letter task. Met carriers (n = 123, 34%) showed steeper linear decline than Val homozygotes (n = 239, 66%); the corresponding contrast explained 2.20% of the variance in change in the entire sample, and 3.41% after excluding individuals at risk for dementia. These effects were not moderated by sex or socioeconomic status. Results are consistent with the hypothesis that normal aging magnifies the effects of common genetic variation on cognitive functioning.

Details

show
hide
Language(s): eng - English
 Dates: 2014-03-242014-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 695716
DOI: 10.1037/a0035201
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Psychology and Aging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Arlington, VA : American Psychological Association (PsycARTICLES)
Pages: - Volume / Issue: 29 (2) Sequence Number: - Start / End Page: 384 - 392 Identifier: ISSN: 0882-7974
CoNE: https://pure.mpg.de/cone/journals/resource/954925548313