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Free keywords:
enantioselective Brønsted acid catalysis; silyl transfer; meso-diols; desymmetrization; asymmetric counteranion-directed catalysis (ACDC)
Abstract:
We report a catalytic enantioselective desymmetrization of meso-1,2-diols by monosilylation using a chiral enantiopure Brønsted acid as catalyst and hexamethyldisilazane (HMDS) as silyl source.