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  Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting.

Caliskan, N., Peske, F., & Rodnina, M. V. (2015). Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting. Trends in Biochemical Sciences, 40(5), 265-274. doi:10.1016/j.tibs.2015.03.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-B76A-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CE10-E
Genre: Journal Article

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2147029.pdf (Publisher version), 2MB
 
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 Creators:
Caliskan, N.1, Author              
Peske, F.1, Author              
Rodnina, M. V.1, Author              
Affiliations:
1Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society, ou_578598              

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Free keywords: gene expression; translation; protein synthesis; decoding; ribosome; mRNA reading frame maintenance
 Abstract: Programmed −1 ribosomal frameshifting (−1PRF) is an mRNA recoding event commonly utilized by viruses and bacteria to increase the information content of their genomes. Recent results have implicated −1PRF in quality control of mRNA and DNA stability in eukaryotes. Biophysical experiments demonstrated that the ribosome changes the reading frame while attempting to move over a slippery sequence of the mRNA – when a roadblock formed by a folded downstream segment in the mRNA stalls the ribosome in a metastable conformational state. The efficiency of −1PRF is modulated not only by cis-regulatory elements in the mRNA but also by trans-acting factors such as proteins, miRNAs, and antibiotics. These recent results suggest a molecular mechanism and new important cellular roles for −1PRF.

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Language(s): eng - English
 Dates: 2015-04-042015-05
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.tibs.2015.03.006
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Title: Trends in Biochemical Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 40 (5) Sequence Number: - Start / End Page: 265 - 274 Identifier: -