English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5

Xiao, Y., Zhai, H., Friederici, A. D., & Jia, F. (2016). The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5. Brain Imaging and Behavior, 10(1), 50-59. doi:10.1007/s11682-015-9362-z.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-BA43-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19C2-6
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Xiao, Yaqiong1, 2, Author              
Zhai, Hongchang1, Author
Friederici, Angela D.2, Author              
Jia, Fucang3, Author
Affiliations:
1School of Education, Guangzhou University, China, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzen, China, ou_persistent22              

Content

show
hide
Free keywords: Resting-state fMRI; Default network; Functional connectivity; Theory of mind; Preschool children
 Abstract: In recent years, research on human functional brain imaging using resting-state fMRI techniques has been increasingly prevalent. The term “default mode” was proposed to describe a baseline or default state of the brain during rest. Recent studies suggested that the default mode network (DMN) is comprised of two functionally distinct subsystems: a dorsal-medial prefrontal cortex (DMPFC) subsystem involved in self-oriented cognition (i.e., theory of mind) and a medial temporal lobe (MTL) subsystem engaged in memory and scene construction; both subsystems interact with the anterior medial prefrontal cortex (aMPFC) and posterior cingulate (PCC) as the core regions of DMN. The present study explored the development of DMN core regions and these two subsystems in both hemispheres from 3- to 5-year-old children. The analysis of the intrinsic activity showed strong developmental changes in both subsystems, and significant changes were specifically found in MTL subsystem, but not in DMPFC subsystem, implying distinct developmental trajectories for DMN subsystems. We found stronger interactions between the DMPFC and MTL subsystems in 5-year-olds, particularly in the left subsystems that support the development of environmental adaptation and relatively complex mental activities. These results also indicate that there is stronger right hemispheric lateralization at age 3, which then changes as bilateral development gradually increases through to age 5, suggesting in turn the hemispheric dominance in DMN subsystems changing with age. The present results provide primary evidence for the development of DMN subsystems in early life, which might be closely related to the development of social cognition in childhood.

Details

show
hide
Language(s): eng - English
 Dates: 20152015-03-112016-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s11682-015-9362-z
PMID: 25759285
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Brain Imaging and Behavior
  Abbreviation : Brain Imaging Behav
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Secaucus, NJ : Springer
Pages: - Volume / Issue: 10 (1) Sequence Number: - Start / End Page: 50 - 59 Identifier: Other: 1931-7557
CoNE: /journals/resource/1931-7557