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要旨:
UNLABELLED: The study of developmental processes in the mouse and other
vertebrates includes the understanding of patterning along the
anterior-posterior, dorsal-ventral and medial- lateral axis.
Specifically, neural development is also of great clinical relevance
because several human neuropsychiatric disorders such as schizophrenia,
autism disorders or drug addiction and also brain malformations are
thought to have neurodevelopmental origins, i.e. pathogenesis initiates
during childhood and adolescence. Impacts during early neurodevelopment
might also predispose to late-onset neurodegenerative disorders, such as
Parkinson's disease. The neural tube develops from its precursor tissue,
the neural plate, in a patterning process that is determined by
compartmentalization into morphogenetic units, the action of local
signaling centers and a well-defined and locally restricted expression
of genes and their interactions. While public databases provide gene
expression data with spatio-temporal resolution, they usually neglect
the genetic interactions that govern neural development. Here, we
introduce Mouse IDGenes, a reference database for genetic interactions
in the developing mouse brain. The database is highly curated and offers
detailed information about gene expressions and the genetic interactions
at the developing mid-/hindbrain boundary. To showcase the predictive
power of interaction data, we infer new Wnt/beta-catenin target genes by
machine learning and validate one of them experimentally. The database
is updated regularly. Moreover, it can easily be extended by the
research community. Mouse IDGenes will contribute as an important
resource to the research on mouse brain development, not exclusively by
offering data retrieval, but also by allowing data input.
DATABASE URL: http://mouseidgenes.helmholtz-muenchen.de.
