非表示:
キーワード:
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要旨:
Imprinted genes and neural stem cells (NSC) play an important role in
the developing and mature brain. A central theme of imprinted gene
function in NSCs is cell survival and G1 arrest to control cell
division, cell-cycle exit, migration and differentiation. Moreover,
genomic imprinting can be epigenetically switched off at some genes to
ensure stem cell quiescence and differentiation. At the genome scale,
imprinted genes are organized in dynamic networks formed by
interchromosomal interactions and transcriptional coregulation of
imprinted and nonimprinted genes. Such multilayered networks may
synchronize NSC activity with the demand from the niche resembling their
roles in adjusting fetal size.
