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  Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders

Rombold, F., Lauterbach, E., Felber, W., Mueller-Oerlinghausen, B., Ahrens, B., Bronisch, T., et al. (2014). Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 18(4), 300-303. doi:10.3109/13651501.2014.940052.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-E14E-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-E14F-E
Genre: Journal Article

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 Creators:
Rombold, Felicitas1, Author
Lauterbach, Eric1, Author
Felber, Werner1, Author
Mueller-Oerlinghausen, Bruno1, Author
Ahrens, Bernd1, Author
Bronisch, Thomas2, Author              
Kilb, Birgit1, Author
Lewitzka, Ute1, Author
Richter, Kneginja1, Author
Broocks, Andreas1, Author
Heuser, Isabella1, Author
Hohagen, Fritz1, Author
Quante, Arnim1, Author
Affiliations:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: Objective. Patients with both major depression and personality disorders have a high risk of suicidal behavior. Lithium is meant to have anti-suicidal properties in patients with affective disorders. The anti-suicidal effect of lithium in patients with affective disorders and comorbid personality disorders has not been investigated yet. Methods. A post-hoc analysis of a subsample of patients with depression and comorbid personality disorder (PD) and a recent suicide attempt (n = 19) from the prospective, placebo-controlled lithium intervention study (N = 167), was conducted. Results. Three patients in the lithium group (n = 8) and two patients in the placebo group (n = 11) presented a suicide attempt throughout the course of the study. No differences related to suicidal behavior could be detected between the placebo group and the group with lithium intervention. Conclusions. On the basis of the small sample size, among patients with comorbid PD, lithium does not seem to have an effect on suicidal behavior in contrast to patients with affective disorders without comorbid PD.

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Language(s): eng - English
 Dates: 2014-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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Title: INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
Source Genre: Journal
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Publ. Info: London, UK : Informa plc
Pages: - Volume / Issue: 18 (4) Sequence Number: - Start / End Page: 300 - 303 Identifier: ISSN: 1365-1501