hide
Free keywords:
-
Abstract:
Background: Abnormal structural/functional connectivity has been
proposed to underlie the pathophysiology of schizophrenia. However, the
biochemical basis of abnormal connectivity remains undefined.
Methods: We undertook a shotgun lipidomic analysis of over 700 lipids
across 26 lipid subclasses in the frontal cortex of schizophrenia
subjects and hippocampus of G72/G30 transgenic mice.
Results: We demonstrate that glycosphingolipids and choline
plasmalogens, structural lipid pools in myelin, are significantly
elevated in the frontal cortex obtained from patients suffering from
schizophrenia and the hippocampus of G72/G30 transgenic mice.
Conclusions: Our data suggest that structural lipid alterations in
oligodendrocyte glycosynapses are responsible for dysconnectivity in
schizophrenia and that increased expression of G72 protein may play a
role in the development of abnormal glycosynapses. (C) 2014 Elsevier B.
V. All rights reserved.
