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  Organization and dynamics of SNARE proteins in the presynaptic membrane.

Milovanovic, D., & Jahn, R. (2015). Organization and dynamics of SNARE proteins in the presynaptic membrane. Frontiers in Physiology, 6: 89. doi:10.3389/fphys.2015.00089.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-BC75-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-19F3-0
Genre: Journal Article

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 Creators:
Milovanovic, D.1, Author              
Jahn, R.1, Author              
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

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Free keywords: SNARE proteins, clustering, membrane domains, hydrophobic interactions, ionic interactions, modularity of cluster formation
 Abstract: Our view of the lateral organization of lipids and proteins in the plasma membrane has evolved substantially in the last few decades. It is widely accepted that many, if not all, plasma membrane proteins and lipids are organized in specific domains. These domains vary widely in size, composition, and stability, and they represent platforms governing diverse cell functions. The presynaptic plasma membrane is a well-studied example of a membrane which undergoes rearrangements, especially during exo- and endocytosis. Many proteins and lipids involved in presynaptic function are known, and major efforts have been made to understand their spatial organization and dynamics. Here, we focus on the mechanisms underlying the organization of SNAREs, the key proteins of the fusion machinery, in distinct domains, and we discuss the functional significance of these clusters.

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Language(s): eng - English
 Dates: 2015-03-192015-04-15
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fphys.2015.00089
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Title: Frontiers in Physiology
Source Genre: Journal
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Pages: 11 Volume / Issue: 6 Sequence Number: 89 Start / End Page: - Identifier: -