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  Dynamics of ionic shifts in cortical spreading depression

Enger, R., Tang, W., Vindedal, G. F., Jensen, V., Helm, P. J., Sprengel, R., et al. (2015). Dynamics of ionic shifts in cortical spreading depression. Cerebral Cortex, 25(11): bhv054, pp. 4469-4476. doi:10.1093/cercor/bhv054.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-BD42-2 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-F2C3-1
Genre: Journal Article

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 Creators:
Enger, Rune, Author
Tang, Wannan1, Author           
Vindedal, Gry Fluge, Author
Jensen, Vidar, Author
Helm, P. Johannes, Author
Sprengel, Rolf1, Author           
Looger, Loren L., Author
Nagelhus, Erlend A.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: Astrocytes, calcium, glutamate, migraine, potassium
 Abstract: Cortical spreading depression is a slowly propagatingwave of near-complete depolarization of brain cells followed by temporary suppression of neuronal activity. Accumulating evidence indicates that cortical spreading depression underlies the migraine aura and that similar waves promote tissue damage in stroke, trauma, and hemorrhage. Cortical spreading depression is characterized by neuronal swelling, profound elevation of extracellular potassium and glutamate, multiphasic blood flow changes, and drop in tissue oxygen tension. The slowspeed of the cortical spreading depressionwave implies that it is mediated by diffusion of a chemical substance, yet the identity of this substance and the pathway it follows are unknown. Intercellular spread between gap junction-coupled neurons or glial cells and interstitial diffusion of K+ or glutamate have been proposed. Here we use extracellular direct current potential recordings, K+-sensitive microelectrodes, and 2-photon imaging with ultrasensitive Ca2+ and glutamate fluorescent probes to elucidate the spatiotemporal dynamics of ionic shifts associated with the propagation of cortical spreading depression in the visual cortex of adult living mice. Our data argue against intercellular spread of Ca2+ carrying the cortical spreading depression wavefront and are in favor of interstitial K+ diffusion, rather than glutamate diffusion, as the leading event in cortical spreading depression

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Language(s): eng - English
 Dates: 2015-04-022015-11-01
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: Other: 8070
DOI: 10.1093/cercor/bhv054
URI: http://www.ncbi.nlm.nih.gov/pubmed/25840424
URI: http://cercor.oxfordjournals.org/content/early/2015/04/01/cercor.bhv054.long
 Degree: -

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 25 (11) Sequence Number: bhv054 Start / End Page: 4469 - 4476 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440