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  Divergent innervation of the olfactory bulb by distinct raphe nuclei

Steinfeld, R., Herb, J. T., Sprengel, R., Schaefer, A. T., & Fukunaga, I. (2015). Divergent innervation of the olfactory bulb by distinct raphe nuclei. The Journal of Comparative Neurology, 523(5), 805-513. doi:10.1002/cne.23713.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-BF01-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-BF02-2
Genre: Journal Article

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JCompNeurol_523_2015_805.pdf (Any fulltext), 648KB
 
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 Creators:
Steinfeld, Raphael1, Author              
Herb, Jan T.1, Author              
Sprengel, Rolf2, Author              
Schaefer, Andreas T.1, Author              
Fukunaga, Izumi1, Author              
Affiliations:
1Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society, ou_1497722              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: AB_1142794; RRIDs: AB_300798; nlx_153890; quantitative image analysis; rAAV
 Abstract: The raphe nuclei provide serotonergic innervation widely in the brain, thought to mediate a variety of neuromodulatory effects. The mammalian olfactory bulb (OB) is a prominent recipient of serotonergic fibers, particularly in the glomerular layer (GL), where they are thought to gate incoming signals from the olfactory nerve. The dorsal raphe nucleus (DRN) and the median raphe nucleus (MRN) are known to densely innervate the OB. The majority of such projections are thought to terminate in the GL, but this has not been explicitly tested. We sought to investigate this using recombinant adeno-associated viruses (rAAV)-mediated expression of green fluorescent protein (GFP)-synaptophysin targeted specifically to neurons of the DRN or the MRN. With DRN injections, labeled fibers were found mostly in the granule cell layer (GCL), not the GL. Conversely, dense labeling in the GL was observed with MRN injections, suggesting that the source of GL innervation is the MRN, not the DRN, as previously thought. The two raphe nuclei thus give dual innervation within the OB, with distinct innervation patterns

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Language(s): eng - English
 Dates: 2014-11-132014-08-012014-11-142015-01-142015-04-01
 Publication Status: Published in print
 Pages: 9
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 Table of Contents: -
 Rev. Method: Peer
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Title: The Journal of Comparative Neurology
Source Genre: Journal
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Publ. Info: Hoboken, N.J. : John Wiley & Sons
Pages: - Volume / Issue: 523 (5) Sequence Number: - Start / End Page: 805 - 513 Identifier: ISSN: 1550-7130
CoNE: https://pure.mpg.de/cone/journals/resource/111088197763336