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  Organization of mitochondrial gene expression in two distinct ribosome-containing assemblies.

Kehrein, K., Schilling, R., Möller-Hergt, B. V., Wurm, C. A., Jakobs, S., Lamkemeyer, T., et al. (2015). Organization of mitochondrial gene expression in two distinct ribosome-containing assemblies. Cell Reports, 10(6), 843-853. doi:10.1016/j.celrep.2015.01.012.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-C085-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1100-5
Genre: Journal Article

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 Creators:
Kehrein, K., Author
Schilling, R., Author
Möller-Hergt, B. V., Author
Wurm, C. A.1, Author              
Jakobs, S.2, Author              
Lamkemeyer, T., Author
Langer, T., Author
Ott, M., Author
Affiliations:
1Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society, ou_578627              
2Research Group of Mitochondrial Structure and Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578566              

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 Abstract: Mitochondria contain their own genetic system that provides subunits of the complexes driving oxidative phosphorylation. A quarter of the mitochondrial proteome participates in gene expression, but how all these factors are orchestrated and spatially organized is currently unknown. Here, we established a method to purify and analyze native and intact complexes of mitochondrial ribosomes. Quantitative mass spectrometry revealed extensive interactions of ribosomes with factors involved in all the steps of posttranscriptional gene expression. These interactions result in large expressosome-like assemblies that we termed mitochondrial organization of gene expression (MIOREX) complexes. Superresolution microscopy revealed that most MIOREX complexes are evenly distributed throughout the mitochondrial network, whereas a subset is present as nucleoid-MIOREX complexes that unite the whole spectrum of organellar gene expression. Our work therefore provides a conceptual framework for the spatial organization of mitochondrial protein synthesis that likely developed to facilitate gene expression in the organelle.

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Language(s): eng - English
 Dates: 2015-02-17
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.celrep.2015.01.012
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Title: Cell Reports
Source Genre: Journal
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Pages: - Volume / Issue: 10 (6) Sequence Number: - Start / End Page: 843 - 853 Identifier: -