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  Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing-remitting multiple sclerosis.

Romascano, D., Meskaldji, D. E., Bonnier, G., Simioni, S., Rotzinger, D., Lin, Y. C., et al. (2015). Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing-remitting multiple sclerosis. Human Brain Mapping, 36(4), 1609-1619. doi:10.1002/hbm.22698.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-C136-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CD0A-6
Genre: Journal Article

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 Creators:
Romascano, D., Author
Meskaldji, D. E., Author
Bonnier, G., Author
Simioni, S., Author
Rotzinger, D., Author
Lin, Y. C., Author
Menegaz, G., Author
Roche, A., Author
Schluep, M., Author
Du Pasquier, R., Author
Richiardi, J., Author
Van De Ville, D., Author
Daducci, A., Author
Sumpf, T., Author
Frahm, J.1, Author              
Thiran, J. P., Author
Krueger, G., Author
Granziera, C., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: connectometry; multicontrast; diffusion MRI; resting-state MRI; multiple sclerosis
 Abstract: Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast connectometry approach to assess the structural and functional integrity of cerebellar networks and connectivity in early MS. Methods: We used diffusion spectrum and resting-state functional MRI (rs-fMRI) to establish the structural and functional cerebellar connectomes in 28 early relapsing-remitting MS patients and 16 healthy controls (HC). We performed multicontrast connectometry by quantifying multiple MRI parameters along the structural tracts (generalized fractional anisotropy-GFA, T1/T2 relaxation times and magnetization transfer ratio) and functional connectivity measures. Subsequently, we assessed multivariate differences in local connections and network properties between MS and HC subjects; finally, we correlated detected alterations with lesion load, disease duration, and clinical scores. Results: In MS patients, a subset of structural connections showed quantitative MRI changes suggesting loss of axonal microstructure and integrity (increased T1 and decreased GFA, P<0.05). These alterations highly correlated with motor, memory and attention in patients, but were independent of cerebellar lesion load and disease duration. Neither network organization nor rs-fMRI abnormalities were observed at this early stage. Conclusion: Multicontrast cerebellar connectometry revealed subtle cerebellar alterations in MS patients, which were independent of conventional disease markers and highly correlated with patient function. Future work should assess the prognostic value of the observed damage

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Language(s): eng - English
 Dates: 2014-11-242015-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.22698
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Pages: - Volume / Issue: 36 (4) Sequence Number: - Start / End Page: 1609 - 1619 Identifier: -