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  Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity Provided by Molecular Dynamics

Mortier, J., Nyakatura, E. K., Reimann, O., Huhmann, S., Daldrop, J. O., Baldauf, C., et al. (2015). Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity Provided by Molecular Dynamics. Journal of Chemical Information and Modeling, 55(3), 495-500. doi:10.1021/ci500689c.

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 Creators:
Mortier, Jeremie1, Author
Nyakatura, Elisabeth K.1, Author
Reimann, Oliver1, Author
Huhmann, Susanne1, Author
Daldrop, Jan O.2, Author
Baldauf, Carsten3, Author           
Wolber, Gerhard1, Author
Miettinen, Markus S.2, Author
Koksch, Beate1, Author
Affiliations:
1Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany, ou_persistent22              
2Department of Physics, Freie Universität Berlin, Arnimallee 14, 14195 Berlin, Germany, ou_persistent22              
3Theory, Fritz Haber Institute, Max Planck Society, ou_634547              

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 Abstract: Involved in numerous key biological functions, protein helix–helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the α-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

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Language(s): eng - English
 Dates: 2015-02-032015-02-032015-03-23
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ci500689c
 Degree: -

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Title: Journal of Chemical Information and Modeling
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Chemical Society
Pages: - Volume / Issue: 55 (3) Sequence Number: - Start / End Page: 495 - 500 Identifier: ISSN: 1549-9596
CoNE: https://pure.mpg.de/cone/journals/resource/954925465222