English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging.

Kallenberg, K., Goldmann, T., Strik, H., Bock, H. C., Mohr, A., Buhk, J. H., et al. (2014). Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging. Folia neuropathologica, 52(3), 226-233. doi:10.5114/fn.2014.45563.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-CBAD-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CD20-1
Genre: Journal Article

Files

show Files
hide Files
:
2152203.pdf (Publisher version), 231KB
Name:
2152203.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Kallenberg, K., Author
Goldmann, T., Author
Strik, H., Author
Bock, H. C., Author
Mohr, A., Author
Buhk, J. H., Author
Frahm, J.1, Author              
Dechent, P., Author
Knauth, M., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

Content

show
hide
Free keywords: glioma, normal appearing white matter, diffusion tensor imaging
 Abstract: Introduction: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter – NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized. Material and methods: Patients’ ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls. Results: Apparent diffusion coefficient levels of the entire contralateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location. Conclusions: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor.

Details

show
hide
Language(s): eng - English
 Dates: 2014-09-26
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.5114/fn.2014.45563
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Folia neuropathologica
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 52 (3) Sequence Number: - Start / End Page: 226 - 233 Identifier: -