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  Clinical proton MR spectroscopy in central nervous system disorders.

Öz, G., Alger, J., Barker, P., Bartha, R., Bizzi, A., Boesch, C., et al. (2014). Clinical proton MR spectroscopy in central nervous system disorders. Radiology, 270(3), 658-679. doi:10.1148/radiol.13130531.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-CBB5-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-2AC2-A
Genre: Journal Article

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 Creators:
Öz, G., Author
Alger, J.R., Author
Barker, P.B., Author
Bartha, R., Author
Bizzi, A., Author
Boesch, C., Author
Bolan, P.J., Author
Brindle, K.M., Author
Cudalbu, C., Author
Dincer, A., Author
Dydak, U., Author
Emir, U.E., Author
Frahm, J.1, Author              
González, R.G., Author
Gruber, S., Author
Gruetter, R., Author
Gupta, R.K., Author
Heerschap, A., Author
Henning, A., Author
Hetherington, H.P., Author
Howe, F.A., AuthorHüppi, P.S., AuthorHurd, R.E., AuthorKantarci, K., AuthorKlomp, D.W.J., AuthorKreis, R., AuthorKruiskamp, M.J., AuthorLeach, M.O., AuthorLin, A.P., AuthorLuijten, P.R., AuthorMarjańska, M., AuthorMaudsley, A.A., AuthorMeyerhoff, D.J., AuthorMountford, C.E., AuthorNelson, S.J., AuthorPamir, M.N., AuthorPan, J.W., AuthorPeet, A.C., AuthorPoptani, H., AuthorPosse, S., AuthorPouwels, P.J.W., AuthorRatai, E.M., AuthorRoss, B.D., AuthorScheenen, T.W.J., AuthorSchuster, C., AuthorSmith, I.C.P., AuthorSoher, B.J., AuthorTkáč, I., AuthorVigneron, D.B., AuthorKauppinen, R.A., Author more..
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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 Abstract: A large body of published work shows that proton (hydrogen 1 [1H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of 1H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of 1H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which 1H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units.

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Language(s): eng - English
 Dates: 2014-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1148/radiol.13130531
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Title: Radiology
Source Genre: Journal
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Pages: - Volume / Issue: 270 (3) Sequence Number: - Start / End Page: 658 - 679 Identifier: -