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  Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis.

Bonnier, G., Roche, A., Romascano, D., Simioni, S., Meskaldji, D., Rotzinger, D., et al. (2014). Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis. Annals of Clinical and Translational Neurology, 1(6), 423-432. doi:10.1002/acn3.68.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-CCD7-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CD23-C
Genre: Journal Article

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 Creators:
Bonnier, G., Author
Roche, A., Author
Romascano, D., Author
Simioni, S., Author
Meskaldji, D., Author
Rotzinger, D., Author
Lin, Y.-C., Author
Menegaz, G., Author
Schluep, M., Author
Pasquier, R. Du, Author
Sumpf, T. J., Author
Frahm, J.1, Author              
Thiran, J.-P., Author
Krueger, G., Author
Granziera, C., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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 Abstract: Introduction: In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques to study brain microstructural alterations in early relapsing-remitting MS (RRMS) patients with minor deficits. Further, we investigated the potential use of advanced MRI to predict functional performances in these patients. Methods: Brain relaxometry (T1, T2, T2*) and magnetization transfer MRI were performed at 3T in 36 RRMS patients and 18 healthy controls (HC). Multicontrast analysis was used to assess for microstructural alterations in normal-appearing (NA) tissue and lesions. A generalized linear model was computed to predict clinical performance in patients using multicontrast MRI data, conventional MRI measures as well as demographic and behavioral data as covariates. Results: Quantitative T2 and T2* relaxometry were significantly increased in temporal normal-appearing white matter (NAWM) of patients compared to HC, indicating subtle microedema (P = 0.03 and 0.004). Furthermore, significant T1 and magnetization transfer ratio (MTR) variations in lesions (mean T1 z-score: 4.42 and mean MTR z-score: 4.09) suggested substantial tissue loss. Combinations of multicontrast and conventional MRI data significantly predicted cognitive fatigue (P = 0.01, Adj-R2 = 0.4), attention (P = 0.0005, Adj-R2 = 0.6), and disability (P = 0.03, Adj-R2 = 0.4). Conclusion: Advanced MRI techniques at 3T, unraveled the nature of brain tissue damage in early MS and substantially improved clinical–radiological correlations in patients with minor deficits, as compared to conventional measures of disease.

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Language(s): eng - English
 Dates: 2014-06-03
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/acn3.68
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Title: Annals of Clinical and Translational Neurology
Source Genre: Journal
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Pages: - Volume / Issue: 1 (6) Sequence Number: - Start / End Page: 423 - 432 Identifier: -