English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Feasibility of source images of computed tomographic angiography to detect the extent of ischemia in hyperacute stroke

Grond, M., Rudolf, J., Schneweis, S., Terstegge, K., Sobesky, J., Kracht, L., et al. (2002). Feasibility of source images of computed tomographic angiography to detect the extent of ischemia in hyperacute stroke. Cerebrovascular Diseases, 13(4), 251-256.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-D4D3-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-D4D4-7
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Grond, Martin1, Author
Rudolf, Jobst2, Author              
Schneweis, Susanne1, Author
Terstegge, K.1, Author
Sobesky, Jan2, Author              
Kracht, Lutz2, Author              
Neveling, M.1, Author
Heiss, Wolf-Dieter3, Author              
Affiliations:
1Univ Cologne, Neurol Klin & Poliklin, Joseph Stelzmann Str 9,; D-50924 Cologne, Germany; Univ Cologne, Neurol Klin & Poliklin, D-50924 Cologne, Germany; Univ Cologne, Inst & Poliklin Radiol Diagnost, D-50924 Cologne, Germany; Max Planck Inst Neurol Res, D-50931 Cologne, Germany, ou_persistent22              
2Klinisches PET, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149663              
3Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149649              

Content

show
hide
Free keywords: ischemic stroke; computed tomographic angiography; positron emission tomography; transcranial Doppler sonography
 Abstract: Copyright 2002 S. Karger AG, Basel.
 Abstract: Background and Purpose: Computed tomographic angiography (CTA) is suggested to be a promising tool for patient selection for thrombolytic therapy of acute stroke. It does not only provide information on intracranial vasculature, but also on the capacity of the collateral circulation and the pattern of poorly perfused brain tissue. The objective of our study was to evaluate whether the presence and size of critically hypoperfused tissue assessed with flow positron emission tomography (PET) as a gold standard can reliably be identified on CTA source images. Methods: Fifteen potential candidates for early thrombolysis underwent CTA 65-170 min (mean 107 min) after the onset of acute anterior circulation stroke. Regional cerebral perfusion was measured between 27 and 86 min (mean 59 min) later with [O-15]-H2O and PET, and the volume of critically hypoperfused cortical tissue was assessed. CTA source images were evaluated by a neuroradiologist and an experienced stroke neurologist. The patients were classified into three groups according to the presumed size of the perfusion deficit on CTA (large, small, no perfusion deficit). Results: PET revealed the presence of critical cortical hypoperfusion in 10 patients, 5 had no critical cortical hypoperfusion. The neuroradiologist correctly identified the presence of a perfusion deficit in all patients, the neurologist had two false negative and one false positive ratings. Concerning the size of the perfusion deficit, there was considerable inaccuracy in both raters. Conclusions: The usefulness of CTA source images in yielding information about the perfusion state of stroke patients in clinical routine should not be overestimated.

Details

show
hide
Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 13388
ISI: 000176096400006
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cerebrovascular Diseases
  Alternative Title : Cerebrovasc. Dis.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 13 (4) Sequence Number: - Start / End Page: 251 - 256 Identifier: ISSN: 1015-9770