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  Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [C- 11]-flumazenil PET

Szelies, B., Sobesky, J., Pawlik, G., Mielke, R., Bauer, B., Herholz, K., et al. (2002). Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [C- 11]-flumazenil PET. European Journal of Neurology, 9(2), 137-142.

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 Creators:
Szelies, Brigitte1, Author
Sobesky, Jan2, Author           
Pawlik, Gunter1, Author
Mielke, Rüdiger1, Author
Bauer, Bernd3, Author           
Herholz, Karl4, Author           
Heiss, Wolf-Dieter4, Author           
Affiliations:
1Neurol Univ Klin, Joseph Stelzmann Str 9, D-50931 Cologne,; Germany; Neurol Univ Klin, D-50931 Cologne, Germany; Max Planck Inst Neurol Res, D-50931 Cologne, Germany, ou_persistent22              
2Klinisches PET, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149663              
3Radiochemistry, Scientific Services and Development, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149672              
4Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149649              

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Free keywords: flumazenil positron; emission tomography; lesional epilepsy; peri-lesional FMZ binding; positron emission tomography/magnetic resonance imaging coregistration
 Abstract: Copyright 2002 BLACKWELL SCIENCE LTD
 Abstract: Individual benzodiazepine receptor (BZR) binding of peri- lesional cortex was investigated in symptomatic epilepsies. Eleven patients aged 19-44 years were studied whose diagnosis was established by medical history, clinical, electroencephalographic, and magnetic resonance imaging (MRI) findings. Three-dimensional [C-11]-flumazenil (FMZ) positron emission tomography and MRI scans were obtained and coregistered. Lesions (five low-grade brain tumours, one AV malformation, one cavernoma, one cystic lesion of unknown aetiology, one traumatic brain injury, one post-operative and one post-haemorrhagic defect) were outlined on individual MRI scans. Adjacent to those lesions, and in homologous contralateral structures, FMZ binding was analysed in four pairs of cortical 9 x 9-mm regions of interest (ROIs) placed on transaxial and coronal slices, respectively, as well as in the lesion volume and its mirror region. Percentage asymmetry ratios were calculated and those at or outside the 90-110% range were operationally defined significant. Peri-lesional FMZ binding asymmetries ranged from 70 to 125%, lesional asymmetries from 38 to 82%. Only one patient showed no significant change, whilst nine exhibited significant reductions of FMZ binding in at least one ROI (3 x 1, 4 x 2, 1 x 3, 1 x 4), and significant increases were observed in two ROIs of another patient. Therefore, peri-lesional disturbances of BZR binding are common but variable in location. Because a close correlation between regional decreases in FMZ binding and spiking activity was recently demonstrated in neocortical epilepsies, abnormal peri-lesional FMZ binding may bear some relation to the mechanisms of epileptogenesis in symptomatic epilepsies.

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Language(s): eng - English
 Dates: 2002-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 13405
ISI: 000174310900003
 Degree: -

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Title: European Journal of Neurology
  Alternative Title : Eur. J. Neurol.
Source Genre: Journal
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Pages: - Volume / Issue: 9 (2) Sequence Number: - Start / End Page: 137 - 142 Identifier: ISSN: 1351-5101