English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Ischemic injury in experimental stroke depends on angiotensin II

Walther, T., Olah, L., Harms, C., Maul, B., Bader, M., Hortnagl, H., et al. (2002). Ischemic injury in experimental stroke depends on angiotensin II. FASEB Journal, 16(2), 169-176.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Walther, T.1, Author
Olah, Laszlo1, Author
Harms, C.1, Author
Maul, B.1, Author
Bader, M.1, Author
Hortnagl, H.1, Author
Schultheiss, H. P.1, Author
Mies, Günter2, Author           
Affiliations:
1Free Univ Berlin, Univ Hosp Benjamin Franklin, Dept Cariol &; Pneumol, Hindenburgdamm 30, D-12200 Berlin, Germany; Free Univ Berlin, Dept Cariol & Pneumol, D-12200 Berlin, Germany; Max Planck Inst Neurol Res, Dept Expt Neurol, Cologne, Germany; Humboldt Univ, Fac Med Charite, Inst Pharmacol & Toxicol, D-1086 Berlin, Germany, ou_persistent22              
2Multimodal Imaging of Brain Metabolism, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149667              

Content

show
hide
Free keywords: A II; focal cerebral ischemia; transgenic mice; penumbra; collateral flow
 Abstract: Copyright 2002 by FASEB
 Abstract: Since pharmacological interactions of the renin-angiotensin system appear to alter the neurological outcome of stroke patients significantly, we examined the effect of elevated levels of angiotensin II and the role of its receptor subtype AT1 in brain infarction in transgenic mice after focal cerebral ischemia. Angiotensinogen-overexpressing and angiotensin receptor AT1 knockout mice underwent 1 h or 24 h permanent middle cerebral artery occlusion (MCAO). The current study revealed a much smaller penumbra size, i.e., brain tissue at risk, in angiotensinogen-overexpressing animals compared with their wild-type subgroup after 1 h MCAO, butanenlarged infarct size after 24 h. In contrast, a smaller lesion area of energy failure and a much larger penumbral area were found in AT1 knockout mice compared with wild-type litter-mates. Lower perfusion thresholds for ATP depletion and protein synthesis inhibition after MCAO in AT1-deficient mice and reduced cell damage in an in vitro model using embryonic neurons of AT1 knockout mice suggest injury mechanisms independent of arterial blood pressure. Our data, therefore, demonstrate a direct correlation between brain angiotensin II and the severity of ischemic injury in experimental stroke.

Details

show
hide
Language(s): eng - English
 Dates: 2002-02
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 13404
ISI: 000174203700021
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: FASEB Journal
  Alternative Title : Faseb J.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 16 (2) Sequence Number: - Start / End Page: 169 - 176 Identifier: ISSN: 0892-6638