Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor 
BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1

Ohashi, Kadaoki; Sequist, Lecia V.; Moran, Teresa; Chmielecki, Juliann; Lin, Ya-Lun; Pan, Yumei; Wang, Lu; de Stanchina, Elisa; Shien, Kazuhiko; Aoe, Keisuke; Toyooka, Shinichi; Kiura, Katsuyuki; Fernandez-Cuesta, Lynnette; Fidias, Panos; Yang, James Chih-Hsin; Miller, Vincent A.; Riely, Gregory J.; Kris, Mark G.; Engelman, Jeffrey A.; Vnencak-Jones, Xindy L.; Dias-Santagata, Dora; Ladanyi, Marc; Pao, William

doi:10.1073/pnas.1203530109

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Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1

Ohashi, K., Sequist, L. V., Moran, T., Chmielecki, J., Lin, Y.-L., Pan, Y., et al. (2012). Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proceedings of the National Academy of Sciences of the United States of America, 109(31), E2127-E2133. doi:10.1073/pnas.1203530109.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-D68B-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-D68C-A

Genre: Journal Article

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Creators:
Ohashi, Kadaoki¹, Author
Sequist, Lecia V.¹, Author
Moran, Teresa¹, Author
Chmielecki, Juliann¹, Author
Lin, Ya-Lun¹, Author
Pan, Yumei¹, Author
Wang, Lu¹, Author
de Stanchina, Elisa¹, Author
Shien, Kazuhiko¹, Author
Aoe, Keisuke¹, Author
Toyooka, Shinichi¹, Author
Kiura, Katsuyuki¹, Author
Fernandez-Cuesta, Lynnette², Author
Fidias, Panos¹, Author
Yang, James Chih-Hsin¹, Author
Miller, Vincent A.¹, Author
Riely, Gregory J.¹, Author
Kris, Mark G.¹, Author
Engelman, Jeffrey A.¹, Author
Vnencak-Jones, Xindy L.¹, Author
Dias-Santagata, Dora¹, AuthorLadanyi, Marc¹, AuthorPao, William¹, Author more..

Affiliations:
1a Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, United States b Massachusetts General Hospital Cancer Center, Boston, MA 02114, United States c Department of Medicine, Harvard Medical School, Boston, MA 02115, United States d Department of Pathology, Harvard Medical School, Boston, MA 02115, United States e Department of Pathology, New York, NY 10065, United States f Anti-Tumor Assessment Core Facility, New York, NY 10065, United States g Thoracic Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, United States h Catalan Institute of Oncology, Universitat Autonoma de Barcelona, Hospital Universitari Germans Trias I Pujol, 08916 Badalona, Barcelona, Spain i Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, United States j Department of Thoracic Surgery, Okayama University Hospital, Okayama, Okayama, Japan k Department of Medical Oncology, National Hospital Organization Yamaguchi-Ube Medical Center, Ube, Yamaguchi 755-0241, Japan l Department of Clinical Research, National Hospital Organization Yamaguchi-Ube Medical Center, Ube, Yamaguchi 755-0241, Japan m Department of Hematology, Oncology, and Respiratory Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Okayama 700-8558, Japan n Graduate Institute of Oncology, Taiwan o Cancer Research Center, National Taiwan University, Taipei 100, Taiwan p Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, United States q Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, United States, ou_persistent22
2Max Planck Society, ou_persistent13

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Language(s): eng - English

Dates: Date issued: 2012

Publication Status: Issued

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Rev. Type: Peer

Identifiers: eDoc: 614866
DOI: 10.1073/pnas.1203530109

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Title: Proceedings of the National Academy of Sciences of the United States of America

Source Genre: Journal

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Pages: - Volume / Issue: 109 (31) Sequence Number: - Start / End Page: E2127 - E2133 Identifier: ISSN: 00278424