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  Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas

Jacobs, A. H., Winkeler, A., Dittmar, C., Gossmann, A., Deckert, M., Kracht, L., et al. (2002). Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas. Technology in Cancer Research and Treatment, 1(3), 187-204.

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 Creators:
Jacobs, Andreas H.1, Author           
Winkeler, A.1, Author           
Dittmar, C., Author
Gossmann, A., Author
Deckert, M., Author
Kracht, Lutz2, Author           
Thiel, Alexander2, Author           
Garlip, G., Author
Hilker, Rüdiger3, Author
Vollmar, Stefan4, Author           
Kummer, Christiane5, Author           
Graf, Rudolf6, Author           
Voges, J., Author
Wienhard, Klaus5, Author           
Herholz, Karl5, Author           
Heiss, Wolf-Dieter5, Author           
Affiliations:
1Gentherapie und Molekulare Bildgebung, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149662              
2Klinisches PET, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149663              
3Max Planck Society, ou_persistent13              
4IT and Electronics Dev., Scientific Services and Development, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149670              
5Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149649              
6Multimodal Imaging of Brain Metabolism, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149667              

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 Abstract: Gliomas are the most common types of brain tumors, which invariably lead to death over months or years. Before new and potentially more effective treatment strategies, such as gene therapy, can be effectively introduced into clinical application the following goals must be reached: (1) the determination of localization, extent and metabolic activity of the glioma; (2) the assessment of functional changes within the surrounding brain tissue; (3) the identification of genetic changes on the molecular level leading to disease; and in addition (4) a detailed non-invasive analysis of both endogenous and exogenous gene expression in animal models and in the clinical setting. Non-invasive imaging of endogenous gene expression by means of positron emission tomography (PET) may reveal insight into the molecular basis of pathogenesis and metabolic activity of the glioma and the extent of treatment response. When exogenous genes are introduced to serve for a therapeutic function, PET imaging techniques may reveal the assessment of the location, magnitude and duration of therapeutic gene expression and its relation to the therapeutic effect. Here, we review the main principles of PET imaging and its key roles in neurooncology research

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 34992
 Degree: -

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Title: Technology in Cancer Research and Treatment
  Alternative Title : Technol Cancer Res Treat.
Source Genre: Journal
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Pages: - Volume / Issue: 1 (3) Sequence Number: - Start / End Page: 187 - 204 Identifier: -