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  Monosymptomatic resting tremor and Parkinson's disease: A multitracer positron emission tomographic study

Ghaemi, M., Raethjen, J., Hilker, R., Rudolf, J., Sobesky, J., Deuschl, G., et al. (2002). Monosymptomatic resting tremor and Parkinson's disease: A multitracer positron emission tomographic study. Movement Disorders, 17(4), 782-788.

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 Creators:
Ghaemi, Mehran1, Author           
Raethjen, J., Author
Hilker, Rüdiger2, Author
Rudolf, Jobst3, Author           
Sobesky, Jan3, Author           
Deuschl, G., Author
Heiss, Wolf-Dieter1, Author           
Affiliations:
1Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149649              
2Max Planck Society, ou_persistent13              
3Klinisches PET, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149663              

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 Abstract: (C) 2002 Movement Disorder Society
 Abstract: We sought to elucidate the relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD). We studied eight mRT patient,, (mean Hoehn and Yahr [HY], 1.1 +/- 0.4), eight patients with PD (mean HY, 1.5 +/- 0.8), who showed all three classic parkinsonian symptoms, and seven age-matched healthy subjects. Subjects underwent cerebral magnetic resonance imaging (MRI) and multitracer positron emission tomography (PET) with 6-[F-18]fluoro-L-dopa (F-dopa), [F-18]fluorodeoxyglucose (FDG), and [C-11]raclopride (RACLO). PD and mRT patients did not show significant differences in F-dopa-, RACLO-, or FDG-PET scans. In F-dopa- and RACLO-PET, significant differences between the pooled patient data and control subjects were found for the following regions: anterior and posterior putamen ipsilateral and contralateral to the more affected body side, and ipsilateral and contralateral putaminal gradients of the K-i values. Furthermore. we found a difference for the normalized glucose values of the whole cerebellum between the control group (0.94 +/- 0.06) and PD patients (1.01 +/- 0.04 P < 0.05) but not for the mRT group (0.97 +/- 0.03). Our findings indicate that monosymptomatic resting tremor represents a phenotype of Parkinson's disease, with a nearly identical striatal dopaminergic deficit and postsynaptic D2-receptor upregulation in both patient groups. We suggest that the cerebellar metabolic hyperactivity in PD is closer related to akinesia and rigidity rather than to tremor

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 34987
 Degree: -

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Title: Movement Disorders
  Alternative Title : Mov. Disord.
Source Genre: Journal
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Pages: - Volume / Issue: 17 (4) Sequence Number: - Start / End Page: 782 - 788 Identifier: -