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  Prospects of molecular imaging in neurology

Jacobs, A. H., Winkeler, A., Dittmar, C., Hilker, R., & Heiss, W.-D. (2002). Prospects of molecular imaging in neurology. Journal of Cellular Biochemistry, (Suppl. 39), 98-109.

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 Creators:
Jacobs, Andreas H.1, Author           
Winkeler, A.1, Author           
Dittmar, Claus2, Author
Hilker, R.2, Author
Heiss, Wolf-Dieter3, Author           
Affiliations:
1Gentherapie und Molekulare Bildgebung, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149662              
2Max Planck Inst Neurol Res, Lab Gene Therapy & Mol Imaging, Ctr; Mol Med ZMMK, Gleueler Str 50, D-50931 Cologne, Germany; Max Planck Inst Neurol Res, Lab Gene Therapy & Mol Imaging, Ctr Mol Med ZMMK, D-50931 Cologne, Germany; Univ Cologne, Dept Neurol, Cologne, Germany, ou_persistent22              
3Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149649              

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Free keywords: molecular imaging; functional imaging; HSV-1 thymidine kinase; FIAU; FHBC; gene therapy; glioma
 Abstract: Molecular imaging aims towards the non-invasive kinetic and quantitative assessment and localization of biological processes of normal and diseased cells in vivo in animal models and humans. Due to technological advances during the past years, imaging of molecular processes is a rapidly growing field, which has the potential of broad applications in the study of cell biology, biochemistry, gene/protein function and regulation, signal transduction, characterization of transgenic animals, development of new treatment strategies (gene or cell- based) and their successful implementation into clinical application. Most importantly, the possibility to study these parameters in the same subject repeatedly over time makes molecular imaging an attractive technology to obtain reliable data and to safe recourse; for example, molecular imaging enables the assessment of an exogenously introduced therapeutic gene and the related alterations of endogenously regulated gene functions directly in the same subject. Therefore, molecular imaging will have great implications especially when molecular diagnostic and treatment modalities have to be translated from experimental into clinical application. Here, we review the three main imaging technologies, which have been developed for studying molecular processes in vivo, the disease models, which have been studied so far, and the potential future applications.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 13134
ISI: 000180777600014
 Degree: -

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Title: Journal of Cellular Biochemistry
  Alternative Title : J. Cell. Biochem.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: (Suppl. 39) Sequence Number: - Start / End Page: 98 - 109 Identifier: ISSN: 0730-2312