English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The correlation between cerebral glucose metabolism and benzodiazepine receptor density in the acute vegetative state

Rudolf, J., Sobesky, J., Ghaemi, M., & Heiss, W.-D. (2002). The correlation between cerebral glucose metabolism and benzodiazepine receptor density in the acute vegetative state. European Journal of Neurology, 9(6), 671-677.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-D9D6-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-D9D7-C
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Rudolf, Jobst1, Author              
Sobesky, Jan1, Author              
Ghaemi, Mehran2, Author              
Heiss, Wolf-Dieter2, Author              
Affiliations:
1Klinisches PET, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149663              
2Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149649              

Content

show
hide
Free keywords: acute vegetative state; C-11-flumazenil; positron emission tomography; post-anoxic syndromes; prognosis
 Abstract: This paper compares the results of parallel positron emission tomography ( PET) studies of regional cerebral glucose metabolism with the radiotracer F-18-fluorodeoxyglucose (FDG) and benzodiazepine receptor (BZR) density by PET using the BZR ligand C-11-flumazenil (FMZ), a tracer of neuronal integrity, in nine patients with acute vegetative state (AVS, duration <1 month). Overall glucose utilization was significantly reduced in AVS in comparison with age-matched controls (global metabolic rate for glucose 26 μmol/100 g/min in AVS vs. 31 μmol/100g/min in controls). FMZ-PET demonstrated a considerable reduction of BZR binding sites in all cortical regions that grossly corresponded to the extent of reduction of cerebral glucose metabolism assessed with FDG-PET, whilst the cerebellum was spared from neuronal loss. In controls, cortical relative flumazenil binding was not lower than five times the average white matter activity, whilst in AVS, nearly all values were below this threshold. There was no relevant overlap of the data of relative umazenil binding between both groups. The comparison of FDG- and FMZ-PET findings in AVS demonstrates that alterations of cerebral glucose consumption do not represent mere functional inactivation, but irreversible structural brain damage.

Details

show
hide
Language(s): eng - English
 Dates: 2002-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 13147
ISI: 000179547400017
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: European Journal of Neurology
  Alternative Title : Eur. J. Neurol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 9 (6) Sequence Number: - Start / End Page: 671 - 677 Identifier: ISSN: 1351-5101