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  The correlation between cerebral glucose metabolism and benzodiazepine receptor density in the acute vegetative state

Rudolf, J., Sobesky, J., Ghaemi, M., & Heiss, W.-D. (2002). The correlation between cerebral glucose metabolism and benzodiazepine receptor density in the acute vegetative state. European Journal of Neurology, 9(6), 671-677.

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Rudolf, Jobst1, Autor           
Sobesky, Jan1, Autor           
Ghaemi, Mehran2, Autor           
Heiss, Wolf-Dieter2, Autor           
Affiliations:
1Klinisches PET, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149663              
2Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149649              

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Schlagwörter: acute vegetative state; C-11-flumazenil; positron emission tomography; post-anoxic syndromes; prognosis
 Zusammenfassung: This paper compares the results of parallel positron emission tomography ( PET) studies of regional cerebral glucose metabolism with the radiotracer F-18-fluorodeoxyglucose (FDG) and benzodiazepine receptor (BZR) density by PET using the BZR ligand C-11-flumazenil (FMZ), a tracer of neuronal integrity, in nine patients with acute vegetative state (AVS, duration <1 month). Overall glucose utilization was significantly reduced in AVS in comparison with age-matched controls (global metabolic rate for glucose 26 μmol/100 g/min in AVS vs. 31 μmol/100g/min in controls). FMZ-PET demonstrated a considerable reduction of BZR binding sites in all cortical regions that grossly corresponded to the extent of reduction of cerebral glucose metabolism assessed with FDG-PET, whilst the cerebellum was spared from neuronal loss. In controls, cortical relative flumazenil binding was not lower than five times the average white matter activity, whilst in AVS, nearly all values were below this threshold. There was no relevant overlap of the data of relative umazenil binding between both groups. The comparison of FDG- and FMZ-PET findings in AVS demonstrates that alterations of cerebral glucose consumption do not represent mere functional inactivation, but irreversible structural brain damage.

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Sprache(n): eng - English
 Datum: 2002-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 13147
ISI: 000179547400017
 Art des Abschluß: -

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Titel: European Journal of Neurology
  Alternativer Titel : Eur. J. Neurol.
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 9 (6) Artikelnummer: - Start- / Endseite: 671 - 677 Identifikator: ISSN: 1351-5101